In vivo testing of a bioabsorbable magnesium alloy serving as total ossicular replacement prostheses

Rebecca Lensing*, Peter Behrens, Peter Paul Müller, Thomas Lenarz, Martin Stieve

*Corresponding author for this work
4 Citations (Scopus)


Magnesium alloys have been investigated in different fields of medicine and represent a promising biomaterial for implants due to characteristics like bioabsorbability and osteoinduction. The objective of this study was to evaluate the usability of magnesium as implant material in middle ear surgery. Magnesium implants were placed into the right middle ear of eighteen New Zealand White rabbits. Nine animals were euthanized after four weeks and nine animals after three month. The petrous bones were removed and embedded in epoxy resin. The specimens were then polished, stained and evaluated with the aid of a light microscope. The histological examination revealed a good biocompatibility. After four weeks, a beginning corrosion of the implant's surface and low amount of trabecular bone formation in the area of the stapes base plate was observed. A considerable degradation of implants and obvious bone formation was found three month after implantation. The magnesium alloy used in the present study partly corroded too fast, so that a complete bone reconstruction could not be established in time. The increased osteoinduction on the stapes base plate resulted in a tight bone-implant bonding. Thus, a promising application of magnesium could be a coating of biomaterials in order to improve the bony integration of implants.

Original languageEnglish
JournalJournal of Biomaterials Applications
Issue number5
Pages (from-to)688-696
Number of pages9
Publication statusPublished - 01.01.2014


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