In vivo p-31-mr-spectroscopy of focal hepatic lesions: Effectiveness of tumor detection in clinical practice and experimental studies of surface coil characteristics and localization technique

Gisbert Brinkmann*, Uwe H. Melchert, Lars Emde, Heike Wolf, Claus Muhle, Joachim Brossmann, Michael Reuter, Martin Heller

*Corresponding author for this work
6 Citations (Scopus)

Abstract

Rationale and Objectives. The influence of partial tumor sampling in a volume of interest (VOI) on the ratios of phosphorus metabolites was examined by localized phosphorus magnetic resonance spectroscopy (P-31-MRS). Experiments were performed to investigate the characteristics of the surface coil used and precession of spatial localization. Methods. A total of 24 patients with liver metastases and 20 volunteers were studied by P-31-MRS. Patients were divided in two groups: VOI < 50% (n = 8) and VOI > 50% (n = 16) occupied by tumor. For evaluation of the surface coil and localization method (image selected in vivo spectroscopy), phantom studies were performed. Results. Superficial focal liver tumors were detectable with a surface coil at a distance within the coil radius. The image selected in vivo spectroscopy permitted the study of phosphorus metabolism in a defined VOI. phosphomonoester/ β-adenosine triphosphate and phosphodiester/β-adenosine triphosphate were elevated significantly in spectra of both patient groups. Conclusions. Detection of small tumor volumes within a VOI filled by less than 50% of the tumor is possible, with results statistically different from that in normal volunteers.

Original languageEnglish
JournalInvestigative Radiology
Volume30
Issue number1
Pages (from-to)56-63
Number of pages8
ISSN0020-9996
DOIs
Publication statusPublished - 01.01.1995

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