TY - JOUR
T1 - In vivo p-31-mr-spectroscopy of focal hepatic lesions
T2 - Effectiveness of tumor detection in clinical practice and experimental studies of surface coil characteristics and localization technique
AU - Brinkmann, Gisbert
AU - Melchert, Uwe H.
AU - Emde, Lars
AU - Wolf, Heike
AU - Muhle, Claus
AU - Brossmann, Joachim
AU - Reuter, Michael
AU - Heller, Martin
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Rationale and Objectives. The influence of partial tumor sampling in a volume of interest (VOI) on the ratios of phosphorus metabolites was examined by localized phosphorus magnetic resonance spectroscopy (P-31-MRS). Experiments were performed to investigate the characteristics of the surface coil used and precession of spatial localization. Methods. A total of 24 patients with liver metastases and 20 volunteers were studied by P-31-MRS. Patients were divided in two groups: VOI < 50% (n = 8) and VOI > 50% (n = 16) occupied by tumor. For evaluation of the surface coil and localization method (image selected in vivo spectroscopy), phantom studies were performed. Results. Superficial focal liver tumors were detectable with a surface coil at a distance within the coil radius. The image selected in vivo spectroscopy permitted the study of phosphorus metabolism in a defined VOI. phosphomonoester/ β-adenosine triphosphate and phosphodiester/β-adenosine triphosphate were elevated significantly in spectra of both patient groups. Conclusions. Detection of small tumor volumes within a VOI filled by less than 50% of the tumor is possible, with results statistically different from that in normal volunteers.
AB - Rationale and Objectives. The influence of partial tumor sampling in a volume of interest (VOI) on the ratios of phosphorus metabolites was examined by localized phosphorus magnetic resonance spectroscopy (P-31-MRS). Experiments were performed to investigate the characteristics of the surface coil used and precession of spatial localization. Methods. A total of 24 patients with liver metastases and 20 volunteers were studied by P-31-MRS. Patients were divided in two groups: VOI < 50% (n = 8) and VOI > 50% (n = 16) occupied by tumor. For evaluation of the surface coil and localization method (image selected in vivo spectroscopy), phantom studies were performed. Results. Superficial focal liver tumors were detectable with a surface coil at a distance within the coil radius. The image selected in vivo spectroscopy permitted the study of phosphorus metabolism in a defined VOI. phosphomonoester/ β-adenosine triphosphate and phosphodiester/β-adenosine triphosphate were elevated significantly in spectra of both patient groups. Conclusions. Detection of small tumor volumes within a VOI filled by less than 50% of the tumor is possible, with results statistically different from that in normal volunteers.
UR - http://www.scopus.com/inward/record.url?scp=0028907924&partnerID=8YFLogxK
U2 - 10.1097/00004424-199501000-00009
DO - 10.1097/00004424-199501000-00009
M3 - Journal articles
C2 - 7759218
AN - SCOPUS:0028907924
SN - 0020-9996
VL - 30
SP - 56
EP - 63
JO - Investigative Radiology
JF - Investigative Radiology
IS - 1
ER -