In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Desmond C. Adler; Yu Chen; Robert Huber; Joseph Schmitt; James Connolly; James G. Fujimoto

doi:10.1117/12.761850

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

Desmond C. Adler, Yu Chen, Robert Huber, Joseph Schmitt, James Connolly, James G. Fujimoto

Institute of Biomedical Optics

Abstract

We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.

Original language	English
Title of host publication	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
Editors	Joseph A. Izatt, James G. Fujimoto, Valery V. Tuchin
Number of pages	1
Volume	6847
Publisher	SPIE
Publication date	2008
Pages	684708
DOIs	https://doi.org/10.1117/12.761850
Publication status	Published - 2008

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Adler, D. C., Chen, Y., Huber, R., Schmitt, J., Connolly, J., & Fujimoto, J. G. (2008). In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers. In J. A. Izatt, J. G. Fujimoto, & V. V. Tuchin (Eds.), Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII (Vol. 6847, pp. 684708). SPIE. https://doi.org/10.1117/12.761850

@inproceedings{e21ffddda01f4eb38d4dd4b990ba3537,

title = "In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers",

abstract = "We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.",

author = "Adler, {Desmond C.} and Yu Chen and Robert Huber and Joseph Schmitt and James Connolly and Fujimoto, {James G.}",

year = "2008",

doi = "10.1117/12.761850",

language = "English",

volume = "6847",

pages = "684708",

editor = "Izatt, {Joseph A.} and Fujimoto, {James G.} and Tuchin, {Valery V.}",

booktitle = "Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII",

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}

Adler, DC, Chen, Y, Huber, R, Schmitt, J, Connolly, J & Fujimoto, JG 2008, In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers. in JA Izatt, JG Fujimoto & VV Tuchin (eds), Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII. vol. 6847, SPIE, pp. 684708. https://doi.org/10.1117/12.761850

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers. / Adler, Desmond C.; Chen, Yu; Huber, Robert et al.
Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII. ed. / Joseph A. Izatt; James G. Fujimoto; Valery V. Tuchin. Vol. 6847 SPIE, 2008. p. 684708.

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

TY - GEN

T1 - In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

AU - Adler, Desmond C.

AU - Chen, Yu

AU - Huber, Robert

AU - Schmitt, Joseph

AU - Connolly, James

AU - Fujimoto, James G.

PY - 2008

Y1 - 2008

N2 - We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.

AB - We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.

U2 - 10.1117/12.761850

DO - 10.1117/12.761850

M3 - Conference contribution

VL - 6847

SP - 684708

BT - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII

A2 - Izatt, Joseph A.

A2 - Fujimoto, James G.

A2 - Tuchin, Valery V.

PB - SPIE

ER -

In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers

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