In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions

A. Bernd; A. Ramirez-Bosca; H. Huber; J. Diaz Alperi; D. Thaci; A. Sewell; E. Quintanilla Almagro; H. Holzmann

In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions

A. Bernd^*, A. Ramirez-Bosca, H. Huber, J. Diaz Alperi, D. Thaci, A. Sewell, E. Quintanilla Almagro, H. Holzmann

^*Corresponding author for this work

Institute of Inflammation Medicine

Johann Wolfgang Goethe-University

24 Citations (Scopus)

Abstract

The in vitro effect of Anapsos®, a water based extract of the naturally occurring fern Polypodium leucotomos (calagualine), on human leukocyte fractions was investigated. Calagualine inhibited interleukin-2 secretion and concanavalin A (Con A) stimulated proliferation of T-lymphocytes in a concentration dependent manner. In contrast, a greatly enhanced secretion of IL-1α, IL-1β and tumor necrosis factor α was induced suggesting a stimulation of monocytes and dendritic cells also present in this system. Endotoxin induced stimulation was excluded. Also in the absence of Con A, calagualine stimulated cytokine production. The presented data show for the first time that calagualine exerts an immunomodulating effect on leukocyte fractions, paving the way for further detailed studies related to possible clinical efficacy.

Original language	English
Journal	Arzneimittel-Forschung/Drug Research
Volume	45
Issue number	8
Pages (from-to)	901-904
Number of pages	4
ISSN	0004-4172
Publication status	Published - 1995

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions",

abstract = "The in vitro effect of Anapsos{\textregistered}, a water based extract of the naturally occurring fern Polypodium leucotomos (calagualine), on human leukocyte fractions was investigated. Calagualine inhibited interleukin-2 secretion and concanavalin A (Con A) stimulated proliferation of T-lymphocytes in a concentration dependent manner. In contrast, a greatly enhanced secretion of IL-1α, IL-1β and tumor necrosis factor α was induced suggesting a stimulation of monocytes and dendritic cells also present in this system. Endotoxin induced stimulation was excluded. Also in the absence of Con A, calagualine stimulated cytokine production. The presented data show for the first time that calagualine exerts an immunomodulating effect on leukocyte fractions, paving the way for further detailed studies related to possible clinical efficacy.",

author = "A. Bernd and A. Ramirez-Bosca and H. Huber and {Diaz Alperi}, J. and D. Thaci and A. Sewell and {Quintanilla Almagro}, E. and H. Holzmann",

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pages = "901--904",

journal = "Arzneimittel-Forschung/Drug Research",

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T1 - In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions

AU - Bernd, A.

AU - Ramirez-Bosca, A.

AU - Huber, H.

AU - Diaz Alperi, J.

AU - Thaci, D.

AU - Sewell, A.

AU - Quintanilla Almagro, E.

AU - Holzmann, H.

PY - 1995

Y1 - 1995

N2 - The in vitro effect of Anapsos®, a water based extract of the naturally occurring fern Polypodium leucotomos (calagualine), on human leukocyte fractions was investigated. Calagualine inhibited interleukin-2 secretion and concanavalin A (Con A) stimulated proliferation of T-lymphocytes in a concentration dependent manner. In contrast, a greatly enhanced secretion of IL-1α, IL-1β and tumor necrosis factor α was induced suggesting a stimulation of monocytes and dendritic cells also present in this system. Endotoxin induced stimulation was excluded. Also in the absence of Con A, calagualine stimulated cytokine production. The presented data show for the first time that calagualine exerts an immunomodulating effect on leukocyte fractions, paving the way for further detailed studies related to possible clinical efficacy.

AB - The in vitro effect of Anapsos®, a water based extract of the naturally occurring fern Polypodium leucotomos (calagualine), on human leukocyte fractions was investigated. Calagualine inhibited interleukin-2 secretion and concanavalin A (Con A) stimulated proliferation of T-lymphocytes in a concentration dependent manner. In contrast, a greatly enhanced secretion of IL-1α, IL-1β and tumor necrosis factor α was induced suggesting a stimulation of monocytes and dendritic cells also present in this system. Endotoxin induced stimulation was excluded. Also in the absence of Con A, calagualine stimulated cytokine production. The presented data show for the first time that calagualine exerts an immunomodulating effect on leukocyte fractions, paving the way for further detailed studies related to possible clinical efficacy.

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M3 - Journal articles

C2 - 7575758

AN - SCOPUS:0029142823

SN - 0004-4172

VL - 45

SP - 901

EP - 904

JO - Arzneimittel-Forschung/Drug Research

JF - Arzneimittel-Forschung/Drug Research

IS - 8

ER -

In vitro studies on the immunomodulating effects of polypodium leucotomos extract on human leukocyte fractions

Abstract

Research Areas and Centers

UN SDGs

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