In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

Leonardo Cecchetti; Tianshi Wang; Ayla Hoogendoorn; Karen T. Witberg; Jurgen M.R. Ligthart; Joost Daemen; Heleen M.M. van Beusekom; Tom Pfeiffer; Robert A. Huber; Jolanda J. Wentzel; Antonius F.W. van der Steen; Gijs van Soest

doi:10.1007/s10554-020-01796-7

In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

Leonardo Cecchetti, Tianshi Wang, Ayla Hoogendoorn, Karen T. Witberg, Jurgen M.R. Ligthart, Joost Daemen, Heleen M.M. van Beusekom, Tom Pfeiffer, Robert A. Huber, Jolanda J. Wentzel, Antonius F.W. van der Steen, Gijs van Soest^*

^*Corresponding author for this work

Institute of Biomedical Optics

9 Citations (Scopus)

Abstract

To quantify the impact of cardiac motion on stent length measurements with Optical Coherence Tomography (OCT) and to demonstrate in vivo OCT imaging of implanted stents, without motion artefacts. The study consists of: clinical data evaluation, simulations and in vivo tests. A comparison between OCT-measured and nominal stent lengths in 101 clinically acquired pullbacks was carried out, followed by a simulation of the effect of cardiac motion on stent length measurements, experimentally and computationally. Both a commercial system and a custom OCT, capable of completing a pullback between two consecutive ventricular contractions, were employed. A 13 mm long stent was implanted in the left anterior descending branch of two atherosclerotic swine and imaged with both OCT systems. The analysis of the clinical OCT images yielded an average difference of 1.1 ± 1.6 mm, with a maximum difference of 7.8 mm and the simulations replicated the statistics observed in clinical data. Imaging with the custom OCT, yielded an RMS error of 0.14 mm at 60 BPM with the start of the acquisition synchronized to the cardiac cycle. In vivo imaging with conventional OCT yielded a deviation of 1.2 mm, relative to the length measured on ex-vivo micro-CT, while the length measured in the pullback acquired by the custom OCT differed by 0.20 mm. We demonstrated motion artefact-free OCT-imaging of implanted stents, using ECG triggering and a rapid pullback.

Original language	English
Journal	International Journal of Cardiovascular Imaging
Volume	36
Issue number	6
Pages (from-to)	1021-1029
Number of pages	9
ISSN	1569-5794
DOIs	https://doi.org/10.1007/s10554-020-01796-7
Publication status	Published - 01.06.2020

Funding

This study was funded by ZonMW (Grant No. IMDI 104003006). The authors Mr. L. Cecchetti, Dr. A. Hoogendoorn, Ms. K.T. Witberg, Mr. J.M.R. Ligthart, Dr. H.M.M. van Beusekom have nothing to disclose. Dr. T. Wang reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. Wang has the right to receive royalties as part of this agreement. Dr. J. Daemen reports grants and personal fees from Acist Medical, grants and personal fees from Boston Scientific, grants and personal fees from Pulsecath, grants from Biotronik, grants and personal fees from Medtronic, grants from Pie Medical, outside the submitted work. Dr. T. Pfeiffer has a patent ‘Method for maintaining the synchronism of a fourier domain mode locked (FDML) laser’ issued and is employed at Optores GmbH, which produces FDML lasers. Dr. R.A. Huber has a patent US7414779B2 with royalties paid. Dr. J.J. Wentzel reports grants from European Research Council, during the conduct of the study. Dr. A.F.W. van der Steen reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van der Steen has the right to receive royalties as part of this agreement. Dr. G. van Soest reports grants from Terumo Corporation, during the conduct of the study, grants from Vivolight Inc., outside the submitted work, and Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van Soest has the right to receive royalties as part of this agreement.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Research Areas and Centers

Academic Focus: Biomedical Engineering

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10.1007/s10554-020-01796-7

Cite this

Cecchetti, L., Wang, T., Hoogendoorn, A., Witberg, K. T., Ligthart, J. M. R., Daemen, J., van Beusekom, H. M. M., Pfeiffer, T., Huber, R. A., Wentzel, J. J., van der Steen, A. F. W., & van Soest, G. (2020). In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT. International Journal of Cardiovascular Imaging, 36(6), 1021-1029. https://doi.org/10.1007/s10554-020-01796-7

@article{98f9c7ff52d24d029a313b07daaded65,

title = "In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT",

abstract = "To quantify the impact of cardiac motion on stent length measurements with Optical Coherence Tomography (OCT) and to demonstrate in vivo OCT imaging of implanted stents, without motion artefacts. The study consists of: clinical data evaluation, simulations and in vivo tests. A comparison between OCT-measured and nominal stent lengths in 101 clinically acquired pullbacks was carried out, followed by a simulation of the effect of cardiac motion on stent length measurements, experimentally and computationally. Both a commercial system and a custom OCT, capable of completing a pullback between two consecutive ventricular contractions, were employed. A 13 mm long stent was implanted in the left anterior descending branch of two atherosclerotic swine and imaged with both OCT systems. The analysis of the clinical OCT images yielded an average difference of 1.1 ± 1.6 mm, with a maximum difference of 7.8 mm and the simulations replicated the statistics observed in clinical data. Imaging with the custom OCT, yielded an RMS error of 0.14 mm at 60 BPM with the start of the acquisition synchronized to the cardiac cycle. In vivo imaging with conventional OCT yielded a deviation of 1.2 mm, relative to the length measured on ex-vivo micro-CT, while the length measured in the pullback acquired by the custom OCT differed by 0.20 mm. We demonstrated motion artefact-free OCT-imaging of implanted stents, using ECG triggering and a rapid pullback.",

author = "Leonardo Cecchetti and Tianshi Wang and Ayla Hoogendoorn and Witberg, \{Karen T.\} and Ligthart, \{Jurgen M.R.\} and Joost Daemen and \{van Beusekom\}, \{Heleen M.M.\} and Tom Pfeiffer and Huber, \{Robert A.\} and Wentzel, \{Jolanda J.\} and \{van der Steen\}, \{Antonius F.W.\} and \{van Soest\}, Gijs",

note = "Funding Information: This study was funded by ZonMW (Grant No. IMDI 104003006). Funding Information: The authors Mr. L. Cecchetti, Dr. A. Hoogendoorn, Ms. K.T. Witberg, Mr. J.M.R. Ligthart, Dr. H.M.M. van Beusekom have nothing to disclose. Dr. T. Wang reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. Wang has the right to receive royalties as part of this agreement. Dr. J. Daemen reports grants and personal fees from Acist Medical, grants and personal fees from Boston Scientific, grants and personal fees from Pulsecath, grants from Biotronik, grants and personal fees from Medtronic, grants from Pie Medical, outside the submitted work. Dr. T. Pfeiffer has a patent {\textquoteleft}Method for maintaining the synchronism of a fourier domain mode locked (FDML) laser{\textquoteright} issued and is employed at Optores GmbH, which produces FDML lasers. Dr. R.A. Huber has a patent US7414779B2 with royalties paid. Dr. J.J. Wentzel reports grants from European Research Council, during the conduct of the study. Dr. A.F.W. van der Steen reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van der Steen has the right to receive royalties as part of this agreement. Dr. G. van Soest reports grants from Terumo Corporation, during the conduct of the study, grants from Vivolight Inc., outside the submitted work, and Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van Soest has the right to receive royalties as part of this agreement. Publisher Copyright: {\textcopyright} 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jun,

day = "1",

doi = "10.1007/s10554-020-01796-7",

language = "English",

volume = "36",

pages = "1021--1029",

journal = "International Journal of Cardiovascular Imaging",

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Cecchetti, L, Wang, T, Hoogendoorn, A, Witberg, KT, Ligthart, JMR, Daemen, J, van Beusekom, HMM, Pfeiffer, T, Huber, RA, Wentzel, JJ, van der Steen, AFW & van Soest, G 2020, 'In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT', International Journal of Cardiovascular Imaging, vol. 36, no. 6, pp. 1021-1029. https://doi.org/10.1007/s10554-020-01796-7

TY - JOUR

T1 - In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

AU - Cecchetti, Leonardo

AU - Wang, Tianshi

AU - Hoogendoorn, Ayla

AU - Witberg, Karen T.

AU - Ligthart, Jurgen M.R.

AU - Daemen, Joost

AU - van Beusekom, Heleen M.M.

AU - Pfeiffer, Tom

AU - Huber, Robert A.

AU - Wentzel, Jolanda J.

AU - van der Steen, Antonius F.W.

AU - van Soest, Gijs

N1 - Funding Information: This study was funded by ZonMW (Grant No. IMDI 104003006). Funding Information: The authors Mr. L. Cecchetti, Dr. A. Hoogendoorn, Ms. K.T. Witberg, Mr. J.M.R. Ligthart, Dr. H.M.M. van Beusekom have nothing to disclose. Dr. T. Wang reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. Wang has the right to receive royalties as part of this agreement. Dr. J. Daemen reports grants and personal fees from Acist Medical, grants and personal fees from Boston Scientific, grants and personal fees from Pulsecath, grants from Biotronik, grants and personal fees from Medtronic, grants from Pie Medical, outside the submitted work. Dr. T. Pfeiffer has a patent ‘Method for maintaining the synchronism of a fourier domain mode locked (FDML) laser’ issued and is employed at Optores GmbH, which produces FDML lasers. Dr. R.A. Huber has a patent US7414779B2 with royalties paid. Dr. J.J. Wentzel reports grants from European Research Council, during the conduct of the study. Dr. A.F.W. van der Steen reports that Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van der Steen has the right to receive royalties as part of this agreement. Dr. G. van Soest reports grants from Terumo Corporation, during the conduct of the study, grants from Vivolight Inc., outside the submitted work, and Erasmus MC has a patent licensing agreement with Terumo Corporation, pertinent to the present study. Dr. van Soest has the right to receive royalties as part of this agreement. Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - To quantify the impact of cardiac motion on stent length measurements with Optical Coherence Tomography (OCT) and to demonstrate in vivo OCT imaging of implanted stents, without motion artefacts. The study consists of: clinical data evaluation, simulations and in vivo tests. A comparison between OCT-measured and nominal stent lengths in 101 clinically acquired pullbacks was carried out, followed by a simulation of the effect of cardiac motion on stent length measurements, experimentally and computationally. Both a commercial system and a custom OCT, capable of completing a pullback between two consecutive ventricular contractions, were employed. A 13 mm long stent was implanted in the left anterior descending branch of two atherosclerotic swine and imaged with both OCT systems. The analysis of the clinical OCT images yielded an average difference of 1.1 ± 1.6 mm, with a maximum difference of 7.8 mm and the simulations replicated the statistics observed in clinical data. Imaging with the custom OCT, yielded an RMS error of 0.14 mm at 60 BPM with the start of the acquisition synchronized to the cardiac cycle. In vivo imaging with conventional OCT yielded a deviation of 1.2 mm, relative to the length measured on ex-vivo micro-CT, while the length measured in the pullback acquired by the custom OCT differed by 0.20 mm. We demonstrated motion artefact-free OCT-imaging of implanted stents, using ECG triggering and a rapid pullback.

AB - To quantify the impact of cardiac motion on stent length measurements with Optical Coherence Tomography (OCT) and to demonstrate in vivo OCT imaging of implanted stents, without motion artefacts. The study consists of: clinical data evaluation, simulations and in vivo tests. A comparison between OCT-measured and nominal stent lengths in 101 clinically acquired pullbacks was carried out, followed by a simulation of the effect of cardiac motion on stent length measurements, experimentally and computationally. Both a commercial system and a custom OCT, capable of completing a pullback between two consecutive ventricular contractions, were employed. A 13 mm long stent was implanted in the left anterior descending branch of two atherosclerotic swine and imaged with both OCT systems. The analysis of the clinical OCT images yielded an average difference of 1.1 ± 1.6 mm, with a maximum difference of 7.8 mm and the simulations replicated the statistics observed in clinical data. Imaging with the custom OCT, yielded an RMS error of 0.14 mm at 60 BPM with the start of the acquisition synchronized to the cardiac cycle. In vivo imaging with conventional OCT yielded a deviation of 1.2 mm, relative to the length measured on ex-vivo micro-CT, while the length measured in the pullback acquired by the custom OCT differed by 0.20 mm. We demonstrated motion artefact-free OCT-imaging of implanted stents, using ECG triggering and a rapid pullback.

UR - https://www.scopus.com/pages/publications/85081036379

U2 - 10.1007/s10554-020-01796-7

DO - 10.1007/s10554-020-01796-7

M3 - Journal articles

C2 - 32112229

AN - SCOPUS:85081036379

SN - 1569-5794

VL - 36

SP - 1021

EP - 1029

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

IS - 6

ER -

In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT

Abstract

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