In search of the neuroprotective mechanism of thiazolidinediones in Parkinson's disease

Dirk A. Ridder; Markus Schwaninger

doi:10.1016/j.expneurol.2012.08.012

In search of the neuroprotective mechanism of thiazolidinediones in Parkinson's disease

Dirk A. Ridder, Markus Schwaninger^*

^*Corresponding author for this work

Institute of Experimental and Clinical Pharmacology and Toxicology

18 Citations (Scopus)

Abstract

The oral antidiabetic thiazolidinediones exert protective effects in models of Parkinson's disease and other neurological diseases. While the antidiabetic effect is due to activation of PPAR?, the mechanisms underlying the neuroprotection are more controversial. It may involve activation of PPAR? blocking inflammation and apoptosis. However, new evidence suggests an antioxidative PPAR?-independent action. Here we discuss recent data on the mode of action of TZDs in models of PD and their implication for the translation into the clinic.

Original language	English
Journal	Experimental Neurology
Volume	238
Issue number	2
Pages (from-to)	133-137
Number of pages	5
ISSN	0014-4886
DOIs	https://doi.org/10.1016/j.expneurol.2012.08.012
Publication status	Published - 01.12.2012

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10.1016/j.expneurol.2012.08.012

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abstract = "The oral antidiabetic thiazolidinediones exert protective effects in models of Parkinson's disease and other neurological diseases. While the antidiabetic effect is due to activation of PPAR?, the mechanisms underlying the neuroprotection are more controversial. It may involve activation of PPAR? blocking inflammation and apoptosis. However, new evidence suggests an antioxidative PPAR?-independent action. Here we discuss recent data on the mode of action of TZDs in models of PD and their implication for the translation into the clinic.",

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AB - The oral antidiabetic thiazolidinediones exert protective effects in models of Parkinson's disease and other neurological diseases. While the antidiabetic effect is due to activation of PPAR?, the mechanisms underlying the neuroprotection are more controversial. It may involve activation of PPAR? blocking inflammation and apoptosis. However, new evidence suggests an antioxidative PPAR?-independent action. Here we discuss recent data on the mode of action of TZDs in models of PD and their implication for the translation into the clinic.

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In search of the neuroprotective mechanism of thiazolidinediones in Parkinson's disease

Abstract

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