Abstract
Bioaffinity NMR is based on the observation of transferred NOE (trNOE) effects which stem from bioactive components in a mixture containing a library of small compounds and a protein target. Zero-quantum coherence signals can interfere with the trNOE cross peaks and, in the worst case, prevent the detection of a bioactive compound in a library. The dephasing of these zero-quantum coherence signals during the experiment significantly improves the bioaffinity NMR spectra obtained and greatly reduces the risk of misinterpretations.
| Original language | English |
|---|---|
| Journal | Magnetic Resonance in Chemistry |
| Volume | 38 |
| Issue number | 4 |
| Pages (from-to) | 315-318 |
| Number of pages | 4 |
| ISSN | 0749-1581 |
| DOIs | |
| Publication status | Published - 04.2000 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
