Improving bioaffinity NMR spectra by means of zero-quantum dephasing

Thomas Weimar*

*Corresponding author for this work
4 Citations (Scopus)


Bioaffinity NMR is based on the observation of transferred NOE (trNOE) effects which stem from bioactive components in a mixture containing a library of small compounds and a protein target. Zero-quantum coherence signals can interfere with the trNOE cross peaks and, in the worst case, prevent the detection of a bioactive compound in a library. The dephasing of these zero-quantum coherence signals during the experiment significantly improves the bioaffinity NMR spectra obtained and greatly reduces the risk of misinterpretations.

Original languageEnglish
JournalMagnetic Resonance in Chemistry
Issue number4
Pages (from-to)315-318
Number of pages4
Publication statusPublished - 04.2000

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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