Abstract
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
Original language | English |
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Journal | Science China Chemistry |
Volume | 55 |
Issue number | 6 |
Pages (from-to) | 1101-1107 |
Number of pages | 7 |
ISSN | 1674-7291 |
DOIs | |
Publication status | Published - 01.06.2012 |