Improved synthesis of rupintrivir

Daizong Lin; Wangke Qian; Rolf Hilgenfeld; Hualiang Jiang; Kaixian Chen; Hong Liu

doi:10.1007/s11426-011-4478-5

Improved synthesis of rupintrivir

Daizong Lin, Wangke Qian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Hong Liu^*

^*Corresponding author for this work

Institute of Biochemistry

2 Citations (Scopus)

Abstract

An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

Original language	English
Journal	Science China Chemistry
Volume	55
Issue number	6
Pages (from-to)	1101-1107
Number of pages	7
ISSN	1674-7291
DOIs	https://doi.org/10.1007/s11426-011-4478-5
Publication status	Published - 01.06.2012

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abstract = "An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.",

author = "Daizong Lin and Wangke Qian and Rolf Hilgenfeld and Hualiang Jiang and Kaixian Chen and Hong Liu",

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T1 - Improved synthesis of rupintrivir

AU - Lin, Daizong

AU - Qian, Wangke

AU - Hilgenfeld, Rolf

AU - Jiang, Hualiang

AU - Chen, Kaixian

AU - Liu, Hong

PY - 2012/6/1

Y1 - 2012/6/1

N2 - An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

AB - An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

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M3 - Journal articles

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VL - 55

SP - 1101

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JO - Science China Chemistry

JF - Science China Chemistry

IS - 6

ER -

Improved synthesis of rupintrivir

Abstract

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