Improved synthesis of rupintrivir

Daizong Lin, Wangke Qian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Hong Liu*

*Corresponding author for this work
2 Citations (Scopus)


An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.

Original languageEnglish
JournalScience China Chemistry
Issue number6
Pages (from-to)1101-1107
Number of pages7
Publication statusPublished - 01.06.2012


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