Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis

Christian Kier; Karsten Meyer-Wiethe; Günter Seidel; Alfred Mertins

doi:10.1007/978-3-642-04271-3_113

Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis

Christian Kier, Karsten Meyer-Wiethe, Günter Seidel, Alfred Mertins

Abstract

Ultrasound contrast imaging is increasingly used to analyze blood perfusion in cases of ischemic or cancerous diseases. Among other imaging methods, the diminution harmonic imaging (DHI), which modells the diminution of contrast agent due to ultrasound pulses, is the most promising because of its speed. However, the current imaging quality of DHI is insufficient for reliable diagnoses. In this paper, we extend the mathematical DHI model to include the part of the intensity signal which is due to tissue reflections and other effects not based on the contrast agent and its concentration in the blood. We show in a phantom experiment with available perfusion ground truth the vast improvements in accuracy of the new model. Our findings also strongly support the theory of a linear relationship between the perfusion speed and the determined perfusion coefficient, which is a large step towards quantitative perfusion measurements.

Original language	English
Title of host publication	Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009
Editors	Guang-Zhong Yang, David Hawkes, Daniel Rueckert, Alison Noble, Chris Taylor
Number of pages	8
Volume	5762 LNCS
Place of Publication	Berlin, Heidelberg
Publisher	Springer Berlin Heidelberg
Publication date	01.09.2009
Edition	PART 2
Pages	935-942
ISBN (Print)	978-3-642-04270-6
ISBN (Electronic)	978-3-642-04271-3
DOIs	https://doi.org/10.1007/978-3-642-04271-3_113
Publication status	Published - 01.09.2009
Event	12th International Conference on Medical Image Computing and Computer-Assisted Intervention - London, United Kingdom Duration: 20.09.2009 → 24.09.2009 Conference number: 77822

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Kier, C., Meyer-Wiethe, K., Seidel, G., & Mertins, A. (2009). Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis. In G-Z. Yang, D. Hawkes, D. Rueckert, A. Noble, & C. Taylor (Eds.), Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009 ( PART 2 ed., Vol. 5762 LNCS, pp. 935-942). ( Lecture Notes in Computer Science; Vol. 5762 LNCS, No. PART 2). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-04271-3_113

Kier, Christian ; Meyer-Wiethe, Karsten ; Seidel, Günter et al. / Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis. Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009. editor / Guang-Zhong Yang ; David Hawkes ; Daniel Rueckert ; Alison Noble ; Chris Taylor. Vol. 5762 LNCS PART 2. ed. Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. pp. 935-942 ( Lecture Notes in Computer Science; PART 2).

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title = "Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis",

abstract = "Ultrasound contrast imaging is increasingly used to analyze blood perfusion in cases of ischemic or cancerous diseases. Among other imaging methods, the diminution harmonic imaging (DHI), which modells the diminution of contrast agent due to ultrasound pulses, is the most promising because of its speed. However, the current imaging quality of DHI is insufficient for reliable diagnoses. In this paper, we extend the mathematical DHI model to include the part of the intensity signal which is due to tissue reflections and other effects not based on the contrast agent and its concentration in the blood. We show in a phantom experiment with available perfusion ground truth the vast improvements in accuracy of the new model. Our findings also strongly support the theory of a linear relationship between the perfusion speed and the determined perfusion coefficient, which is a large step towards quantitative perfusion measurements. ",

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Kier, C, Meyer-Wiethe, K, Seidel, G & Mertins, A 2009, Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis. in G-Z Yang, D Hawkes, D Rueckert, A Noble & C Taylor (eds), Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009. PART 2 edn, vol. 5762 LNCS, Lecture Notes in Computer Science, no. PART 2, vol. 5762 LNCS, Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 935-942, 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, London, United Kingdom, 20.09.09. https://doi.org/10.1007/978-3-642-04271-3_113

Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis. / Kier, Christian; Meyer-Wiethe, Karsten; Seidel, Günter et al.
Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009. ed. / Guang-Zhong Yang; David Hawkes; Daniel Rueckert; Alison Noble; Chris Taylor. Vol. 5762 LNCS PART 2. ed. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. p. 935-942 ( Lecture Notes in Computer Science; Vol. 5762 LNCS, No. PART 2).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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T1 - Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis

AU - Kier, Christian

AU - Meyer-Wiethe, Karsten

AU - Seidel, Günter

AU - Mertins, Alfred

N1 - Conference code: 77822

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Ultrasound contrast imaging is increasingly used to analyze blood perfusion in cases of ischemic or cancerous diseases. Among other imaging methods, the diminution harmonic imaging (DHI), which modells the diminution of contrast agent due to ultrasound pulses, is the most promising because of its speed. However, the current imaging quality of DHI is insufficient for reliable diagnoses. In this paper, we extend the mathematical DHI model to include the part of the intensity signal which is due to tissue reflections and other effects not based on the contrast agent and its concentration in the blood. We show in a phantom experiment with available perfusion ground truth the vast improvements in accuracy of the new model. Our findings also strongly support the theory of a linear relationship between the perfusion speed and the determined perfusion coefficient, which is a large step towards quantitative perfusion measurements.

AB - Ultrasound contrast imaging is increasingly used to analyze blood perfusion in cases of ischemic or cancerous diseases. Among other imaging methods, the diminution harmonic imaging (DHI), which modells the diminution of contrast agent due to ultrasound pulses, is the most promising because of its speed. However, the current imaging quality of DHI is insufficient for reliable diagnoses. In this paper, we extend the mathematical DHI model to include the part of the intensity signal which is due to tissue reflections and other effects not based on the contrast agent and its concentration in the blood. We show in a phantom experiment with available perfusion ground truth the vast improvements in accuracy of the new model. Our findings also strongly support the theory of a linear relationship between the perfusion speed and the determined perfusion coefficient, which is a large step towards quantitative perfusion measurements.

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DO - 10.1007/978-3-642-04271-3_113

M3 - Conference contribution

SN - 978-3-642-04270-6

VL - 5762 LNCS

T3 - Lecture Notes in Computer Science

SP - 935

EP - 942

BT - Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009

A2 - Yang, Guang-Zhong

A2 - Hawkes, David

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PB - Springer Berlin Heidelberg

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ER -

Kier C, Meyer-Wiethe K, Seidel G, Mertins A. Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis. In Yang G-Z, Hawkes D, Rueckert D, Noble A, Taylor C, editors, Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2009. PART 2 ed. Vol. 5762 LNCS. Berlin, Heidelberg: Springer Berlin Heidelberg. 2009. p. 935-942. ( Lecture Notes in Computer Science; PART 2). doi: 10.1007/978-3-642-04271-3_113

Improved Modelling of Ultrasound Contrast Agent Diminution for Blood Perfusion Analysis

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