Improved Estimation of the Magnetic Nanoparticle Diameter with a Magnetic Particle Spectrometer and Combined Fields

S. Biederer, T. Knopp, T. F. Sattel, M. Erbe, T. M. Buzug

Abstract

Introduction: In the tomographic imaging technique magnetic particle imaging (MPI), the spatial distribution of super-paramagnetic iron-oxide nanoparticles (SPIOs) can be visualized in real-time [1, 2, 3, 4]. MPI takes advantage of the nonlinear magnetization behavior of the SPIOs. In simulations it has been shown [5, 6] that the iron-core diameter has a high impact on the received signal and, thus, also on the imaging quality. For prediction of the imaging quality or for a model-based reconstruction [7], the knowledge of the exact ironcore size distribution is indispensable. However, an estimation of the iron-core size e.g. by transmission electron microscopy is complicated and time consuming. A magnetic particle spectrometer (MPS) exploits the same physical effect as used in MPI. Based on MPS measurements, a new method to estimate the iron-core size distribution was proposed [8]. In this contribution an improvement of this estimation method is presented by using combined excitation fields.
Original languageEnglish
Pages954
Number of pages1
Publication statusPublished - 2010

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