Improved Elastic Medical Image Registration Using Mutual Information

Konstantin Ens, Hanno Schumacher, Astrid Franz, Bernd Fischer, J.P.W. Pluim, J.M. Reinhardt


One of the future-oriented areas of medical image processing is to develop fast and exact algorithms for image registration. By joining multi-modal images we are able to compensate the disadvantages of one imaging modality with the advantages of another modality. For instance, a Computed Tomography (CT) image containing the anatomy can be combined with metabolic information of a Positron Emission Tomography (PET) image. It is quite conceivable that a patient will not have the same position in both imaging systems. Furthermore some regions for instance in the abdomen can vary in shape and position due to different filling of the rectum. So a multi-modal image registration is needed to calculate a deformation field for one image in order to maximize the similarity between the two images, described by a so-called distance measure. In this work, we present a method to adapt a multi-modal distance measure, here mutual information (MI), with weighting masks. These masks are used to enhance relevant image structures and suppress image regions which otherwise would disturb the registration process. The performance of our method is tested on phantom data and real medical images.
Original languageEnglish
Title of host publication Medical Imaging 2007: Image Processing
EditorsJoseph M. Reinhardt, Josien P. W. Pluim
Number of pages8
Place of PublicationSan Diego, CA, United States
Publication date08.03.2007
Pages6512 - 6512 - 8
Article number65122C
ISBN (Print)978-081946630-3
Publication statusPublished - 08.03.2007
EventMedical Imaging 2007: Image Processing - San Diego, United States
Duration: 17.02.200722.02.2007
Conference number: 70570


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