TY - JOUR
T1 - Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice
AU - Gabriel, Gülsah
AU - Feldmann, Friederike
AU - Reimer, Rudolph
AU - Thiele, Swantje
AU - Fischer, Meike
AU - Hartmann, Enno
AU - Bader, Michael
AU - Ebihara, Hideki
AU - Hoenen, Thomas
AU - Feldmann, Heinz
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-α7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-α7 was not sufficient to increase survival rates among mice infected with EBOV.
AB - Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-α7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-α7 was not sufficient to increase survival rates among mice infected with EBOV.
UR - http://www.scopus.com/inward/record.url?scp=84943274820&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiv240
DO - 10.1093/infdis/jiv240
M3 - Journal articles
C2 - 26185094
AN - SCOPUS:84943274820
SN - 0022-1899
VL - 212
SP - S316-S321
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -
