Importin-α7 Is Involved in the Formation of Ebola Virus Inclusion Bodies but Is Not Essential for Pathogenicity in Mice

Gülsah Gabriel*, Friederike Feldmann, Rudolph Reimer, Swantje Thiele, Meike Fischer, Enno Hartmann, Michael Bader, Hideki Ebihara, Thomas Hoenen, Heinz Feldmann

*Corresponding author for this work
2 Citations (Scopus)

Abstract

Ebola virus (EBOV) protein 24 antagonizes the host interferon (IFN) response by hijacking select nuclear importin-α isoforms. Thereby, it blocks STAT1-mediated IFN-α/β and IFN-γ synthesis. However, owing to the lack of importin-α knockout animal models in the past, their role in EBOV pathogenesis remained largely unknown. Here, we demonstrate that importin-α7 is involved in the formation of EBOV inclusion bodies and replication. However, deletion of the gene encoding importin-α7 was not sufficient to increase survival rates among mice infected with EBOV.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume212
Pages (from-to)S316-S321
ISSN0022-1899
DOIs
Publication statusPublished - 01.01.2015

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