Importin α7 is essential for zygotic genome activation and early mouse development

Franziska Rother; Tatiana Shmidt; Elena Popova; Alexander Krivokharchenko; Stefanie Hügel; Larissa Vilianovich; Michael Ridders; Katja Tenner; Natalia Alenina; Matthias Köhler; Enno Hartmann; Michael Bader

doi:10.1371/journal.pone.0018310

Importin α7 is essential for zygotic genome activation and early mouse development

Franziska Rother, Tatiana Shmidt, Elena Popova, Alexander Krivokharchenko, Stefanie Hügel, Larissa Vilianovich, Michael Ridders, Katja Tenner, Natalia Alenina, Matthias Köhler, Enno Hartmann, Michael Bader^*

^*Corresponding author for this work

Institute of Biology

20 Citations (Scopus)

Abstract

Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.

Original language	English
Article number	e18310
Journal	PLoS ONE
Volume	6
Issue number	3
ISSN	1553-7390
DOIs	https://doi.org/10.1371/journal.pone.0018310
Publication status	Published - 04.04.2011

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abstract = "Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.",

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AU - Rother, Franziska

AU - Shmidt, Tatiana

AU - Popova, Elena

AU - Krivokharchenko, Alexander

AU - Hügel, Stefanie

AU - Vilianovich, Larissa

AU - Ridders, Michael

AU - Tenner, Katja

AU - Alenina, Natalia

AU - Köhler, Matthias

AU - Hartmann, Enno

AU - Bader, Michael

PY - 2011/4/4

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AB - Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes.

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JO - PLoS ONE

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Importin α7 is essential for zygotic genome activation and early mouse development

Abstract

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