In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE). coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)