Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus

Tilman Schlegelberger; Jörn Kekow; Wolfgang L. Gross

doi:10.1016/0090-1229(86)90041-3

Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus

Tilman Schlegelberger^*, Jörn Kekow, Wolfgang L. Gross

^*Corresponding author for this work

Clinic of Rheumatology

University of Kiel

9 Citations (Scopus)

Abstract

In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE). coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.

Original language	English
Journal	Clinical Immunology and Immunopathology
Volume	40
Issue number	2
Pages (from-to)	365-370
Number of pages	6
ISSN	0090-1229
DOIs	https://doi.org/10.1016/0090-1229(86)90041-3
Publication status	Published - 08.1986

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/0090-1229(86)90041-3

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@article{96f6cb69d72740b29a72b2afdb564019,

title = "Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus",

abstract = "In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE). coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.",

author = "Tilman Schlegelberger and J{\"o}rn Kekow and Gross, {Wolfgang L.}",

year = "1986",

month = aug,

doi = "10.1016/0090-1229(86)90041-3",

language = "English",

volume = "40",

pages = "365--370",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

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}

Schlegelberger, T, Kekow, J & Gross, WL 1986, 'Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus', Clinical Immunology and Immunopathology, vol. 40, no. 2, pp. 365-370. https://doi.org/10.1016/0090-1229(86)90041-3

Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus. / Schlegelberger, Tilman; Kekow, Jörn; Gross, Wolfgang L.
In: Clinical Immunology and Immunopathology, Vol. 40, No. 2, 08.1986, p. 365-370.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus

AU - Schlegelberger, Tilman

AU - Kekow, Jörn

AU - Gross, Wolfgang L.

PY - 1986/8

Y1 - 1986/8

N2 - In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE). coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.

AB - In a case of monozygotic twins discordant for systemic lupus erythematosus (SLE). coculture experiments with isologous (i.e., genetically identical) lymphocytes were performed. Adequate T-helper-cell function in the SLE twin was demonstrated. Lack of B-cell responsiveness to T-cell-dependent and T-cell-independent polyclonal activators points to a T-cell-independent B-cell maturation defect in the SLE twin.

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U2 - 10.1016/0090-1229(86)90041-3

DO - 10.1016/0090-1229(86)90041-3

M3 - Journal articles

C2 - 2941197

AN - SCOPUS:0022539588

SN - 0090-1229

VL - 40

SP - 365

EP - 370

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 2

ER -

Impaired T-cell-independent B-cell maturation in systemic lupus erythematosus: Coculture experiments in monozygotic twins concordant for Klinefelter's syndrome but discordant for systemic lupus erythematosus

Abstract

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