TY - JOUR
T1 - Impaired serum cortisol stress response is a predictor of early relapse
AU - Junghanns, K.
AU - Backhaus, J.
AU - Tietz, U.
AU - Lange, W.
AU - Bernzen, J.
AU - Wetterling, T.
AU - Rink, L.
AU - Driessen, M.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/3
Y1 - 2003/3
N2 - Aims: to investigate a possible association of cortisol stress response during early abstention with relapse. Methods: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. Results: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. Conclusions: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.
AB - Aims: to investigate a possible association of cortisol stress response during early abstention with relapse. Methods: Thirty-six alcohol-dependent males, half of them with a comorbid anxiety disorder, and 15 healthy controls were exposed to a standardized psychosocial stress test. Thirty-one of the patients were assessed for relapse 6 weeks after discharge. Results: The relapsers showed almost no cortisol responses in the stress test. Comorbid anxiety disorder influenced neither stress response nor relapse. Conclusions: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.
UR - http://www.scopus.com/inward/record.url?scp=0037347506&partnerID=8YFLogxK
U2 - 10.1093/alcalc/agg052
DO - 10.1093/alcalc/agg052
M3 - Journal articles
C2 - 12634269
AN - SCOPUS:0037347506
SN - 0735-0414
VL - 38
SP - 189
EP - 193
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
IS - 2
ER -
