Impact of intra-Aortic balloon counterpulsation on all-cause mortality among patients with Takotsubo syndrome complicated by cardiogenic shock: Results from the German-Italian-Spanish (GEIST) registry

Francesco Santoro, Iván J. Núñez Gil, Thomas Stiermaier, Ibrahim El-Battrawy, Christian Moeller, Federico Guerra, Giuseppina Novo, Luca Arcari, Beatrice Musumeci, Luca Cacciotti, Enrica Mariano, Francesco Romeo, Michele Cannone, Pasquale Caldarola, Irene Giannini, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Roberta Montisci, Luigi MeloniPasquale Raimondo, Matteo Di Biase, Manuel Almendro-Delia, Alessandro Sionis, Aitor Uribarri, Ibrahim Akin, Holger Thiele, Ingo Eitel, Natale Daniele Brunetti*

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Aims: Takotsubo syndrome (TTS) is an acute and reversible left ventricular dysfunction and can be complicated by cardiogenic shock (CS). However, few data are available on optimal care in TTS complicated by CS. Aim of this study was to evaluate short-and long-Term impact of intra-Aortic balloon pumping (IABP) on mortality in this setting. Methods and results: In a multi-centre, international registry on TTS, 2248 consecutive patients were enrolled from 38 centres from Germany, Italy, and Spain. Of the 2248 patients, 212 (9.4%) experienced CS. Patients with CS had a higher prevalence of diabetes (27% vs. 19%), male sex (25% vs. 10%), and right ventricular involvement (10% vs. 5%) (P < 0.01 in all cases). Forty-Three patients with CS (20% of 212) received IABP within 8â h (interquartile range 4-18) after admission. No differences in terms of age, gender, cardiovascular risk factors, and admission left ventricular ejection fraction were found among patients with and without IABP. There were no significant differences in terms of 30-day mortality (16% vs. 17%, P = 0.98), length of hospitalization (18.9 vs. 16.7 days, P = 0.51), and need of invasive ventilation (35% vs. 41%, P = 0.60) among two groups: 30-day survival was not significantly different even after propensity score adjustment (log-rank P = 0.73). At 42-month follow-up, overall mortality in patients with CS and TTS was 35%, not significantly different between patients receiving IABP and not (37% vs. 35%, P = 0.72). Conclusions: In a large multi-centre observational registry, the use of IABP was not associated with lower mortality rates at short-and long-Term follow-up in patients with TTS and CS.

Original languageEnglish
Article numberoead003
JournalEuropean Heart Journal Open
Volume3
Issue number1
DOIs
Publication statusPublished - 01.01.2023

Research Areas and Centers

  • Centers: Cardiological Center Luebeck (UHZL)

DFG Research Classification Scheme

  • 205-12 Cardiology, Angiology

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