Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Dirk Friedrich; Roger A. Fecher; Jan Rupp; George S. Deepe

doi:10.1016/j.micinf.2016.10.008

Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Dirk Friedrich^*, Roger A. Fecher, Jan Rupp, George S. Deepe

^*Corresponding author for this work

Institute of Medical Microbiology

University of Cincinnati

10 Citations (Scopus)

Abstract

Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

Original language	English
Journal	Microbes and Infection
Volume	19
Issue number	3
Pages (from-to)	204-209
Number of pages	6
ISSN	1286-4579
DOIs	https://doi.org/10.1016/j.micinf.2016.10.008
Publication status	Published - 01.03.2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.1016/j.micinf.2016.10.008

Cite this

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title = "Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity",

abstract = "Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.",

author = "Dirk Friedrich and Fecher, \{Roger A.\} and Jan Rupp and Deepe, \{George S.\}",

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T1 - Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

AU - Friedrich, Dirk

AU - Fecher, Roger A.

AU - Rupp, Jan

AU - Deepe, George S.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

AB - Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

UR - https://www.scopus.com/pages/publications/85008263900

U2 - 10.1016/j.micinf.2016.10.008

DO - 10.1016/j.micinf.2016.10.008

M3 - Journal articles

C2 - 27810563

AN - SCOPUS:85008263900

SN - 1286-4579

VL - 19

SP - 204

EP - 209

JO - Microbes and Infection

JF - Microbes and Infection

IS - 3

ER -

Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Abstract

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