TY - JOUR
T1 - Impact of Dose-Volume Parameters of Parotid Glands on Xerostomia in Patients Irradiated for Head-and-Neck Cancer
AU - Rades, Dirk
AU - Warwas, Britta
AU - Cremers, Florian
AU - Gerull, Karsten
AU - Idel, Christian
AU - Bruchhage, Karl L.
AU - Hakim, Samer G.
AU - Schild, Steven E.
N1 - Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2022/7
Y1 - 2022/7
N2 - Background/Aim: Optimal planning of radiotherapy for head-and-neck cancers should consider the risk of xerostomia. This study investigated the prognostic value of dose-volume parameters of the parotid glands. Patients and Methods: Dose-volume parameters were evaluated for xerostomia in 145 patients including D40 (minimum dose to 40% of corresponding parotid volume), D60 (minimum dose to 60%), D80 (minimum dose to 80%), and mean dose of ipsilateral, contralateral, and bilateral parotid glands. Results: Grade ≥2 xerostomia was significantly associated with D40 of ipsilateral and all parameters of bilateral glands; trends were found for all other parameters. Grade ≥3 xerostomia was significantly associated with D80 of bilateral glands; trends were found for other parameters of ipsilateral and bilateral glands. Conclusion: Since grade ≥2 xerostomia was associated with all parameters, D40, D60, and D80 did not provide additional information to mean doses. D80 of bilateral glands is a new factor and more predictive than mean dose regarding grade ≥3 xerostomia.
AB - Background/Aim: Optimal planning of radiotherapy for head-and-neck cancers should consider the risk of xerostomia. This study investigated the prognostic value of dose-volume parameters of the parotid glands. Patients and Methods: Dose-volume parameters were evaluated for xerostomia in 145 patients including D40 (minimum dose to 40% of corresponding parotid volume), D60 (minimum dose to 60%), D80 (minimum dose to 80%), and mean dose of ipsilateral, contralateral, and bilateral parotid glands. Results: Grade ≥2 xerostomia was significantly associated with D40 of ipsilateral and all parameters of bilateral glands; trends were found for all other parameters. Grade ≥3 xerostomia was significantly associated with D80 of bilateral glands; trends were found for other parameters of ipsilateral and bilateral glands. Conclusion: Since grade ≥2 xerostomia was associated with all parameters, D40, D60, and D80 did not provide additional information to mean doses. D80 of bilateral glands is a new factor and more predictive than mean dose regarding grade ≥3 xerostomia.
UR - http://www.scopus.com/inward/record.url?scp=85133250672&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1925b594-78eb-36f3-af15-7dcdbc25f535/
U2 - 10.21873/anticanres.15841
DO - 10.21873/anticanres.15841
M3 - Journal articles
C2 - 35790294
AN - SCOPUS:85133250672
SN - 0250-7005
VL - 42
SP - 3551
EP - 3556
JO - Anticancer Research
JF - Anticancer Research
IS - 7
ER -
