Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen; Katharina Kelling; Christine Dittmer; Klaus Diedrich; Michael Friedrich; Marc Thill

Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen, Katharina Kelling, Christine Dittmer, Klaus Diedrich, Michael Friedrich, Marc Thill^*

^*Corresponding author for this work

Clinic of Gynecology and Obstetrics

62 Citations (Scopus)

Abstract

Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

Original language	English
Journal	Anticancer Research
Volume	31
Issue number	12
Pages (from-to)	4359-4367
Number of pages	9
ISSN	0250-7005
Publication status	Published - 01.12.2011

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SDG 3 Good Health and Well-being

Cite this

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title = "Impact of cyclooxygenase-2 in breast cancer",

abstract = "Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.",

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T1 - Impact of cyclooxygenase-2 in breast cancer

AU - Hoellen, Friederike

AU - Kelling, Katharina

AU - Dittmer, Christine

AU - Diedrich, Klaus

AU - Friedrich, Michael

AU - Thill, Marc

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

AB - Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

UR - https://www.scopus.com/pages/publications/84855184409

M3 - Scientific review articles

C2 - 22199301

AN - SCOPUS:84855184409

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VL - 31

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EP - 4367

JO - Anticancer Research

JF - Anticancer Research

IS - 12

ER -

Impact of cyclooxygenase-2 in breast cancer

Abstract

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