Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen; Katharina Kelling; Christine Dittmer; Klaus Diedrich; Michael Friedrich; Marc Thill

Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen, Katharina Kelling, Christine Dittmer, Klaus Diedrich, Michael Friedrich, Marc Thill^*

^*Corresponding author for this work

Clinic of Gynecology and Obstetrics

32 Citations (Scopus)

Abstract

Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

Original language	English
Journal	Anticancer Research
Volume	31
Issue number	12
Pages (from-to)	4359-4367
Number of pages	9
ISSN	0250-7005
Publication status	Published - 01.12.2011

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Cite this

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AU - Friedrich, Michael

AU - Thill, Marc

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AB - Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

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M3 - Scientific review articles

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JO - Anticancer Research

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Impact of cyclooxygenase-2 in breast cancer

Abstract

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