Impact of cyclooxygenase-2 in breast cancer

Friederike Hoellen, Katharina Kelling, Christine Dittmer, Klaus Diedrich, Michael Friedrich, Marc Thill*

*Corresponding author for this work
32 Citations (Scopus)


Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.

Original languageEnglish
JournalAnticancer Research
Issue number12
Pages (from-to)4359-4367
Number of pages9
Publication statusPublished - 01.12.2011


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