Immunopathology of ANCA-Associated Vasculitis

Csernok Elena; Müller Antje; Wolfgang L. Gross

doi:10.2169/internalmedicine.38.759

Immunopathology of ANCA-Associated Vasculitis

Csernok Elena, Müller Antje, Wolfgang L. Gross^*

^*Corresponding author for this work

Department of Rheumatology and Clinical Immunology

49 Citations (Scopus)

Abstract

During the past few years remarkable progress has been achieved in the understanding of the pathogenic mechanisms leading to vascular inflammation and injury in ANCA-associated vasulitides (AAV): Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg Strauss syndrome (CSS). In this paper we review the immunopathology of these diseases by describing the role of autoantibodies (ANCA), dysregulation and abnormalities at the cellular level, genetic background and environmental factors that predispose to autoimmune response.

Original language	English
Journal	Internal Medicine
Volume	38
Issue number	10
Pages (from-to)	759-765
Number of pages	7
ISSN	0918-2918
DOIs	https://doi.org/10.2169/internalmedicine.38.759
Publication status	Published - 10.1999

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.2169/internalmedicine.38.759

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AB - During the past few years remarkable progress has been achieved in the understanding of the pathogenic mechanisms leading to vascular inflammation and injury in ANCA-associated vasulitides (AAV): Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg Strauss syndrome (CSS). In this paper we review the immunopathology of these diseases by describing the role of autoantibodies (ANCA), dysregulation and abnormalities at the cellular level, genetic background and environmental factors that predispose to autoimmune response.

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Immunopathology of ANCA-Associated Vasculitis

Abstract

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