Immunopathology of ANCA-Associated Vasculitis

Csernok Elena, Müller Antje, Wolfgang L. Gross*

*Corresponding author for this work
45 Citations (Scopus)

Abstract

During the past few years remarkable progress has been achieved in the understanding of the pathogenic mechanisms leading to vascular inflammation and injury in ANCA-associated vasulitides (AAV): Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg Strauss syndrome (CSS). In this paper we review the immunopathology of these diseases by describing the role of autoantibodies (ANCA), dysregulation and abnormalities at the cellular level, genetic background and environmental factors that predispose to autoimmune response.

Original languageEnglish
JournalInternal Medicine
Volume38
Issue number10
Pages (from-to)759-765
Number of pages7
ISSN0918-2918
DOIs
Publication statusPublished - 10.1999

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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