Immunohistochemistry of proteins for DNA mismatch repair in correlation to prognostic factors of mammarian cancer

Frank Köster*, Andreas Schröer, Dorothea Fischer, Anja Kathrin Horn, Klaus Diedrich, Michael Friedrich

*Corresponding author for this work
8 Citations (Scopus)


Mutations in genes of the DNA mismatch repair system (MMR) are strongly linked to the development of hereditary non-polyposis colorectal cancer and play a significant role in sporadic cancer too. Besides the repair of chromosomal mismatches produced during replication, the MMR is the linkage of DNA mismatches to cell cycle control. Proteins of the MMR are necessary for the induction of apoptosis in response to non-tolerable amounts of DNA damage. We correlated the immunoreactivity of the MMR proteins hMSH2, hMLH1 and PMS2 to the immunoreaction of p53, the proliferation marker Ki67 and clinical prognosis factors such as tumor grading and staging, steroid receptor expression and hemangiosis carcinomatosa or lymphangiosis carcinomatosa in 200 samples from patients with diagnosed breast cancer. No correlation could be detected among the expression of the three MMR-proteins hMSH2, hMLH1 and PMS2. The expression of hMSH2 correlated positively with the expression of p53, with the appearance of distant metastases, low differentiation and the appearance of hemangiosis carcinomatosa and lymphangiosis carcinomatosa, while it negatively correlated with the expression of the estrogen receptor. No correlation was detected between hMLH1 or PMS2 and any of the investigated factors. The expression of hMSH2 seems to be related with predictors of an unfavorable course of disease in breast cancer.

Original languageEnglish
JournalOncology Reports
Issue number5
Pages (from-to)1223-1227
Number of pages5
Publication statusPublished - 05.2007

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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