Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas

Andreas Schröer; Frank Köster; Dorothea Fischer; Ralph Martin Dubitscher; Astrid Woll-Hermann; Klaus Diedrich; Michael Friedrich; Darius Salehin

Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas

Andreas Schröer, Frank Köster^*, Dorothea Fischer, Ralph Martin Dubitscher, Astrid Woll-Hermann, Klaus Diedrich, Michael Friedrich, Darius Salehin

^*Corresponding author for this work

Department of Gynecology and Obstetrics

6 Citations (Scopus)

Abstract

Background: The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease. Patients and Methods: Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC. Results: Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found. Conclusion: MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.

Original language	English
Journal	Anticancer Research
Volume	29
Issue number	11
Pages (from-to)	4833-4837
Number of pages	5
ISSN	0250-7005
Publication status	Published - 01.11.2009

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

Cite this

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title = "Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas",

abstract = "Background: The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease. Patients and Methods: Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC. Results: Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found. Conclusion: MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.",

author = "Andreas Schr{\"o}er and Frank K{\"o}ster and Dorothea Fischer and Dubitscher, \{Ralph Martin\} and Astrid Woll-Hermann and Klaus Diedrich and Michael Friedrich and Darius Salehin",

year = "2009",

month = nov,

day = "1",

language = "English",

volume = "29",

pages = "4833--4837",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "11",

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TY - JOUR

T1 - Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas

AU - Schröer, Andreas

AU - Köster, Frank

AU - Fischer, Dorothea

AU - Dubitscher, Ralph Martin

AU - Woll-Hermann, Astrid

AU - Diedrich, Klaus

AU - Friedrich, Michael

AU - Salehin, Darius

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Background: The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease. Patients and Methods: Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC. Results: Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found. Conclusion: MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.

AB - Background: The human Mut-S-homolog-2 (MSH2) is part of the DNA mismatch repair system (MMR). Mutations in genes of the MMR are a predisposition to hereditary non-polyposis colorectal cancer (HNPCC). In women, MMR gene mutations may lead to primary endometrial cancer (EC). The important function of the MMR for the integrity of the DNA during replication makes it probable that the MMR might also be involved in the development and the course of sporadic carcinomas. Insufficient MMR activity or expression levels could be prognostic markers of the disease. Patients and Methods: Immunohistochemical analysis of MSH2 was performed in 86 tumor samples from patients with EC. Results: Compared to known tumor markers, namely estrogen and progesterone receptors, histopathological grading, TNM stage and FIGO classification, no significant correlation between MSH2 immunoreactivity and EC was found. Conclusion: MSH2 immunohistochemical analysis is not of prognostic value for endometrial carcinoma.

UR - https://www.scopus.com/pages/publications/75149133712

M3 - Journal articles

C2 - 20032443

AN - SCOPUS:75149133712

SN - 0250-7005

VL - 29

SP - 4833

EP - 4837

JO - Anticancer Research

JF - Anticancer Research

IS - 11

ER -

Immunohistochemistry of DNA mismatch repair enzyme MSH2 is not correlated with prognostic data from endometrial carcinomas

Abstract

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