Immunohistochemical visualization of the enteric nervous system using antibodies against Protein gene product (PGP) 9.5

Heinz Jürgen Krammer*, Süleyman Tuna Karahan, Elisabeth Rumpel, Matthias Klinger, Wolfgang Kühnel

*Corresponding author for this work
67 Citations (Scopus)

Abstract

Both the investigation of the enteric nervous system and the diagnosis of its pathological changes require reliable staining methods. In order to assess the potential of protein gene product (PGP) 9.5 as a marker for the enteric nervous system, we examined its immunoreaction in whole-mount preparations of the guinea pig and porcine small intestine, using a rabbit polyclonal antiserum.The immunohistochemical technique reveals the fundamental architectural features of the ganglionic and aganglionic plexuses. Furthermore, it enables a reproducible and differentiated visualization of the enteric nerve cells to be made, so that the various nerve cell types can be morphologically identified.

Original languageEnglish
JournalAnnals of Anatomy
Volume175
Issue number4
Pages (from-to)321-325
Number of pages5
ISSN0940-9602
DOIs
Publication statusPublished - 1993

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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