Projects per year
Abstract
Background: Pemphigoid diseases are a heterogeneous group of autoimmune blistering disorders characterized by predominant deposition of immunoglobulin G or immunoglobulin A autoantibodies against structural proteins of the dermoepidermal junction (DEJ). Sole linear immunoglobulin M (IgM) deposits at the DEJ in pemphigoid diseases have been observed; however, IgM-specific target antigens have not been identified. Objective: Characterization of patients with IgM pemphigoid. Methods: Skin biopsy specimens and sera from IgM-positive patients were assessed using histopathology, direct and indirect immunofluorescence microscopy, enzyme-linked immunosorbent assays, immunoblotting, cryosection assay, complement fixation test, and internalization assays. Results: Tissue-bound linear IgM deposits along the DEJ and circulating IgM autoantibodies against type XVII collagen (Col17) were detected. These circulating IgM autoantibodies showed no complement activating or blister inducing capacity, but the ability of Col17 internalization ex vivo. Limitations: Limited number of patients. Conclusion: This study provides further evidence for the role of IgM autoantibodies in pemphigoid disease and highlights Col17 as a target antigen in IgM pemphigoid.
Original language | English |
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Journal | Journal of the American Academy of Dermatology |
Volume | 85 |
Issue number | 6 |
Pages (from-to) | 1486-1492 |
Number of pages | 7 |
ISSN | 0190-9622 |
DOIs | |
Publication status | Published - 12.2021 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
- Centers: Center for Research on Inflammation of the Skin (CRIS)
DFG Research Classification Scheme
- 2.21-05 Immunology
- 2.22-19 Dermatology
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EXC 2167: Precision Medicine in Chronic Inflammation (PMI)
Schreiber, S., Baines, J. F., Bosch, T. C. G., Buyx, A., Erdmann, J., Franke, A., Huber, R., Klein, C., Köhl, J., König, I. R., Lange, C., Laudes, M., Lieb, W., Ludwig, R., Nebel, A., Niemann, S., Rabe, K. F., Riemekasten, G., Rose-John, S., Rosenstiel, P. C., Schulenburg, H., Schwarz, K., Traulsen, A., Weidinger, S. & Zillikens, D.
01.01.19 → …
Project: DFG Projects › DFG Cluster of Excellence
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CRU 303: Pemphigoid Diseases - Molecular Pathways and their Therapeutic Potential
Sadik, C., Zillikens, D., Ibrahim, S., Baines, J. F., Schmidt, E., Köhl, J., Ehlers, M., Hirose, M., König, P., Ludwig, R., Manz, R., Schwaninger, M., Beek, N., Erdmann, J., König, I. R., Verschoor, A., Karsten, C., Bieber, K. & Busch, H. S.
01.04.15 → 31.12.23
Project: DFG Projects › DFG Joint Research: Research Units/Clinical Research Units