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Abstract
Its stable particle structure combined with its high immunogenicity makes the hepatitis A virus (HAV) a perfect carrier to expose foreign epitopes to the host immune system. In an earlier report [Beneduce, F., Kusov, Y., Klinger, M., Gauss-Müller, V., Morace, G., 2002. Chimeric hepatitis A virus particles presenting a foreign epitope (HIV gp41) at their surface. Antiviral Res. 55, 369-377] chimeric virus-like particles (HAV-gp41) were described that carried at their surface the dominant gp41 epitope 2F5 (2F5e) of the human immunodeficiency virus HIV-1. Extending this work, we now report that chimeric virus HAV-gp41 replicates in HAV-susceptible cells as well as in non-human primates. Infected marmosets developed both an anti-HAV and anti-2F5 epitope immune response. Furthermore, an HIV-neutralizing antibody response was elicited in guinea pigs immunized with HAV-gp41 chimeric particles. The results demonstrate that the replication-competent chimeric HAV-gp41 can serve as either a live or a subunit vaccine for eliciting of antibodies directed against a foreign antigenic epitope.
Original language | English |
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Journal | Antiviral Research |
Volume | 73 |
Issue number | 2 |
Pages (from-to) | 101-111 |
Number of pages | 11 |
ISSN | 0166-3542 |
DOIs | |
Publication status | Published - 02.2007 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
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Dive into the research topics of 'Immunogenicity of a chimeric hepatitis A virus (HAV) carrying the HIV gp41 epitope 2F5'. Together they form a unique fingerprint.Projects
- 1 Finished
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Der Wechsel von Translation zu Replikation im Lebenszyklus des Hepatitis A Virus (HAV): Ein Zell-Virus-Zusammenspiel
Gauss-Müller, V. (Principal Investigator (PI))
01.01.06 → 31.12.08
Project: DFG Projects › DFG Individual Projects