Immediate-type hypersensitivity reactions after platelet transfusion.

D. Wilhelm*, A. Fiebelkorn, S. Görg, M. Klouche, H. Klüter, H. Kirchner

*Corresponding author for this work
1 Citation (Scopus)


Non-febrile non-haemolytic transfusion reactions (NHTR) after platelet substitution vary from severe (anaphylactic shock) to mild (urticaria) forms. Although the symptoms of these immediate-type hypersensitivity reactions are well documented, little is known about their pathophysiology. We therefore examined sera from patients suffering from different forms of NHTR regarding total serum IgE, specific IgE antibodies and complement activity. Our results show that specific IgE antibodies in the recipients' sera were clearly associated with immediate-type hypersensitivity NHTR and conclude that atopic patients have a higher risk of suffering from these forms of transfusion reactions than non-atopic patients. Allergy diagnostic for patients who require platelet transfusions should be considered in case of multiple platelet substitution.

Original languageEnglish
JournalBeiträge zur Infusionstherapie und Transfusionsmedizin = Contributions to infusion therapy and transfusion medicine
Pages (from-to)448-452
Number of pages5
Publication statusPublished - 1994


Dive into the research topics of 'Immediate-type hypersensitivity reactions after platelet transfusion.'. Together they form a unique fingerprint.

Cite this