Imaging Inflammation – From Whole Body Imaging to Cellular Resolution

Tuula Peñate Medina; Jan Philip Kolb; Gereon Hüttmann; Robert Huber; Oula Peñate Medina; Linh Ha; Patricia Ulloa; Naomi Larsen; Arianna Ferrari; Magdalena Rafecas; Mark Ellrichmann; Mariya S. Pravdivtseva; Mariia Anikeeva; Jana Humbert; Marcus Both; Jennifer E. Hundt; Jan Bernd Hövener

doi:10.3389/fimmu.2021.692222

Imaging Inflammation – From Whole Body Imaging to Cellular Resolution

Tuula Peñate Medina^*, Jan Philip Kolb, Gereon Hüttmann, Robert Huber, Oula Peñate Medina, Linh Ha, Patricia Ulloa, Naomi Larsen, Arianna Ferrari, Magdalena Rafecas, Mark Ellrichmann, Mariya S. Pravdivtseva, Mariia Anikeeva, Jana Humbert, Marcus Both, Jennifer E. Hundt, Jan Bernd Hövener

^*Corresponding author for this work

Abstract

Imaging techniques have evolved impressively lately, allowing whole new concepts like multimodal imaging, personal medicine, theranostic therapies, and molecular imaging to increase general awareness of possiblities of imaging to medicine field. Here, we have collected the selected (3D) imaging modalities and evaluated the recent findings on preclinical and clinical inflammation imaging. The focus has been on the feasibility of imaging to aid in inflammation precision medicine, and the key challenges and opportunities of the imaging modalities are presented. Some examples of the current usage in clinics/close to clinics have been brought out as an example. This review evaluates the future prospects of the imaging technologies for clinical applications in precision medicine from the pre-clinical development point of view.

Original language	English
Article number	692222
Journal	Frontiers in Immunology
Volume	12
Pages (from-to)	692222
ISSN	1664-3224
DOIs	https://doi.org/10.3389/fimmu.2021.692222
Publication status	Published - 24.06.2021

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Peñate Medina, T., Kolb, J. P., Hüttmann, G., Huber, R., Peñate Medina, O., Ha, L., Ulloa, P., Larsen, N., Ferrari, A., Rafecas, M., Ellrichmann, M., Pravdivtseva, M. S., Anikeeva, M., Humbert, J., Both, M., Hundt, J. E., & Hövener, J. B. (2021). Imaging Inflammation – From Whole Body Imaging to Cellular Resolution. Frontiers in Immunology, 12, 692222. [692222]. https://doi.org/10.3389/fimmu.2021.692222

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Peñate Medina, T, Kolb, JP , Hüttmann, G , Huber, R, Peñate Medina, O, Ha, L, Ulloa, P, Larsen, N, Ferrari, A, Rafecas, M, Ellrichmann, M, Pravdivtseva, MS, Anikeeva, M, Humbert, J, Both, M, Hundt, JE & Hövener, JB 2021, 'Imaging Inflammation – From Whole Body Imaging to Cellular Resolution', Frontiers in Immunology, vol. 12, 692222, pp. 692222. https://doi.org/10.3389/fimmu.2021.692222

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AU - Peñate Medina, Tuula

AU - Kolb, Jan Philip

AU - Hüttmann, Gereon

AU - Huber, Robert

AU - Peñate Medina, Oula

AU - Ha, Linh

AU - Ulloa, Patricia

AU - Larsen, Naomi

AU - Ferrari, Arianna

AU - Rafecas, Magdalena

AU - Ellrichmann, Mark

AU - Pravdivtseva, Mariya S.

AU - Anikeeva, Mariia

AU - Humbert, Jana

AU - Both, Marcus

AU - Hundt, Jennifer E.

AU - Hövener, Jan Bernd

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Imaging Inflammation – From Whole Body Imaging to Cellular Resolution

Abstract

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