IgG4-associated lung disease with granulomatous lesions: Coexistence of two entities or the spectrum of one disease? Koexistenz zweier Entitäten oder das Spektrum einer Erkrankung?

Translated title of the contribution: IgG4-associated lung disease with granulomatous lesions: Coexistence of two entities or the spectrum of one disease?

Christiane Kümpers*, Lars Tharun, Florian Stellmacher, Ulf Greinert, Katharina May, Sven Perner

*Corresponding author for this work

Abstract

A 54-year-old patient with a history of pulmonary tuberculosis and occupational exposure to dust in early adulthood presented with symptoms of coughing with sputum, weight loss, occasional night sweats, and thoracic pain. Non-necrotizing granulomatosis in lung and lymph-node biopsies indicated sarcoidosis. Combined immunosuppressive therapy did not lead to an improvement. An atypical lung resectate with fibroinflammatory changes and obliterative endothelialitis may finally lead to the diagnosis of IgG4-associated lung disease with a bronchovascular pattern of involvement. The question discussed here is whether this is a coexistence of IgG4-associated lung disease with sarcoidosis or the spectrum of one disease.

Translated title of the contributionIgG4-associated lung disease with granulomatous lesions: Coexistence of two entities or the spectrum of one disease?
Original languageGerman
JournalPathologe
Volume42
Issue number1
Pages (from-to)95-101
Number of pages7
ISSN0172-8113
DOIs
Publication statusPublished - 01.02.2021

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