IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Adrian Baican; Yoshiaki Hirako; Zelmira Lazarova; Kim B. Yancey; Detlef Zillikens; Cassian Sitaru

doi:10.1016/j.jaad.2005.05.001

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Adrian Baican, Yoshiaki Hirako, Zelmira Lazarova, Kim B. Yancey, Detlef Zillikens^*, Cassian Sitaru

^*Corresponding author for this work

Clinic of Dermatology, Allergology and Venerology

9 Citations (Scopus)

Abstract

We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

Original language	English
Journal	Journal of the American Academy of Dermatology
Volume	53
Issue number	3
Pages (from-to)	516-521
Number of pages	6
ISSN	0190-9622
DOIs	https://doi.org/10.1016/j.jaad.2005.05.001
Publication status	Published - 09.2005

Funding

Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jaad.2005.05.001

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@article{5aaeca6191bf4d158f7d36f1ed75332d,

title = "IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease",

abstract = "We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.",

author = "Adrian Baican and Yoshiaki Hirako and Zelmira Lazarova and Yancey, \{Kim B.\} and Detlef Zillikens and Cassian Sitaru",

note = "Funding Information: Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft. ",

year = "2005",

month = sep,

doi = "10.1016/j.jaad.2005.05.001",

language = "English",

volume = "53",

pages = "516--521",

journal = "Journal of the American Academy of Dermatology",

issn = "0190-9622",

publisher = "Elsevier Inc.",

number = "3",

}

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease. / Baican, Adrian; Hirako, Yoshiaki; Lazarova, Zelmira et al.
In: Journal of the American Academy of Dermatology, Vol. 53, No. 3, 09.2005, p. 516-521.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

AU - Baican, Adrian

AU - Hirako, Yoshiaki

AU - Lazarova, Zelmira

AU - Yancey, Kim B.

AU - Zillikens, Detlef

AU - Sitaru, Cassian

N1 - Funding Information: Funding source: Grant Zi 439/6-1 from the Deutsche Forschungsgemeinschaft.

PY - 2005/9

Y1 - 2005/9

N2 - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

AB - We describe a patient with widespread skin lesions and circulating IgG autoantibodies to both type VII collagen and laminin 5. Although autoantibodies to type VII collagen belonged to IgG2, IgG3, and IgG4 subclasses, laminin 5 was targeted exclusively by IgG3 autoantibodies. Interestingly, despite the presence of IgG3 autoantibodies, the patient's serum failed to fix complement to the dermoepidermal junction. In addition, these autoantibodies did not recruit and activate leukocytes or induce dermoepidermal separation in skin sectioned by cryostat. We report a most unusual case of an autoimmune subepidermal blistering with an exclusive IgG3 reactivity to laminin 5.

UR - https://www.scopus.com/pages/publications/23944434751

U2 - 10.1016/j.jaad.2005.05.001

DO - 10.1016/j.jaad.2005.05.001

M3 - Journal articles

C2 - 16112366

AN - SCOPUS:23944434751

SN - 0190-9622

VL - 53

SP - 516

EP - 521

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

IS - 3

ER -

IgG autoantibodies to type VII collagen and an exclusive IgG3 reactivity to the laminin α3 chain in a patient with an autoimmune subepidermal blistering disease

Abstract

Funding

UN SDGs

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