Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma

A. Bakhshandeh; I. Bruns; A. Traynor; H. I. Robins; K. Eberhardt; A. Demedts; E. Kaukel; G. Koschel; U. Gatzemeier; Th Kohlmann; K. Dalhoff; E. M. Ehlers; Y. Gruber; R. Zumschlinge; S. Hegewisch-Becker; S. O. Peters; G. J. Wiedemann

doi:10.1016/S0169-5002(02)00536-6

Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma

A. Bakhshandeh^*, I. Bruns, A. Traynor, H. I. Robins, K. Eberhardt, A. Demedts, E. Kaukel, G. Koschel, U. Gatzemeier, Th Kohlmann, K. Dalhoff, E. M. Ehlers, Y. Gruber, R. Zumschlinge, S. Hegewisch-Becker, S. O. Peters, G. J. Wiedemann

^*Corresponding author for this work

26 Citations (Scopus)

Abstract

We performed a phase II study combining 41.8°C whole body hyperthermia with ICE chemotherapy, i.e. ifosfamide (5 g/m²), carboplatin (300 mg/m²) and etoposide (150 mg/m² on days 2 and 3), administered every 4 weeks, for patients with malignant pleural mesothelioma. Of 27 chemonäive, non-metastatic patients enrolled, 25 patients were evaluable for response. Overall response rate was 20% (five partial remissions; 95% CI 8.9-39.1%). Median survival time from the start of treatment for all patients was 76.6 weeks (95% CI 65.4-87.8 weeks). Progression free survival for all patients measured 29.6 weeks (95% CI 24.4-34.7 weeks). One year overall survival was 68% and 2 year overall survival was 20%. Major treatment toxicities included grade 3/4 neutropenia and thrombocytopenia in 74 and 33% of treatment cycles, respectively. One patient died due to sepsis. These promising results are consistent with continued clinical investigation; a phase III clinical trial with whole body hyperthermia as the independent variable has been initiated.

Original language	English
Journal	Lung Cancer
Volume	39
Issue number	3
Pages (from-to)	339-345
Number of pages	7
ISSN	0169-5002
DOIs	https://doi.org/10.1016/S0169-5002(02)00536-6
Publication status	Published - 01.03.2003

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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Bakhshandeh, A., Bruns, I., Traynor, A., Robins, H. I., Eberhardt, K., Demedts, A., Kaukel, E., Koschel, G., Gatzemeier, U., Kohlmann, T., Dalhoff, K., Ehlers, E. M., Gruber, Y., Zumschlinge, R., Hegewisch-Becker, S., Peters, S. O., & Wiedemann, G. J. (2003). Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma. Lung Cancer, 39(3), 339-345. https://doi.org/10.1016/S0169-5002(02)00536-6

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title = "Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma",

abstract = "We performed a phase II study combining 41.8°C whole body hyperthermia with ICE chemotherapy, i.e. ifosfamide (5 g/m2), carboplatin (300 mg/m2) and etoposide (150 mg/m2 on days 2 and 3), administered every 4 weeks, for patients with malignant pleural mesothelioma. Of 27 chemon{\"a}ive, non-metastatic patients enrolled, 25 patients were evaluable for response. Overall response rate was 20\% (five partial remissions; 95\% CI 8.9-39.1\%). Median survival time from the start of treatment for all patients was 76.6 weeks (95\% CI 65.4-87.8 weeks). Progression free survival for all patients measured 29.6 weeks (95\% CI 24.4-34.7 weeks). One year overall survival was 68\% and 2 year overall survival was 20\%. Major treatment toxicities included grade 3/4 neutropenia and thrombocytopenia in 74 and 33\% of treatment cycles, respectively. One patient died due to sepsis. These promising results are consistent with continued clinical investigation; a phase III clinical trial with whole body hyperthermia as the independent variable has been initiated.",

author = "A. Bakhshandeh and I. Bruns and A. Traynor and Robins, \{H. I.\} and K. Eberhardt and A. Demedts and E. Kaukel and G. Koschel and U. Gatzemeier and Th Kohlmann and K. Dalhoff and Ehlers, \{E. M.\} and Y. Gruber and R. Zumschlinge and S. Hegewisch-Becker and Peters, \{S. O.\} and Wiedemann, \{G. J.\}",

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doi = "10.1016/S0169-5002(02)00536-6",

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Bakhshandeh, A, Bruns, I, Traynor, A, Robins, HI, Eberhardt, K, Demedts, A, Kaukel, E, Koschel, G, Gatzemeier, U, Kohlmann, T, Dalhoff, K, Ehlers, EM, Gruber, Y, Zumschlinge, R, Hegewisch-Becker, S, Peters, SO & Wiedemann, GJ 2003, 'Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma', Lung Cancer, vol. 39, no. 3, pp. 339-345. https://doi.org/10.1016/S0169-5002(02)00536-6

TY - JOUR

T1 - Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma

AU - Bakhshandeh, A.

AU - Bruns, I.

AU - Traynor, A.

AU - Robins, H. I.

AU - Eberhardt, K.

AU - Demedts, A.

AU - Kaukel, E.

AU - Koschel, G.

AU - Gatzemeier, U.

AU - Kohlmann, Th

AU - Dalhoff, K.

AU - Ehlers, E. M.

AU - Gruber, Y.

AU - Zumschlinge, R.

AU - Hegewisch-Becker, S.

AU - Peters, S. O.

AU - Wiedemann, G. J.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - We performed a phase II study combining 41.8°C whole body hyperthermia with ICE chemotherapy, i.e. ifosfamide (5 g/m2), carboplatin (300 mg/m2) and etoposide (150 mg/m2 on days 2 and 3), administered every 4 weeks, for patients with malignant pleural mesothelioma. Of 27 chemonäive, non-metastatic patients enrolled, 25 patients were evaluable for response. Overall response rate was 20% (five partial remissions; 95% CI 8.9-39.1%). Median survival time from the start of treatment for all patients was 76.6 weeks (95% CI 65.4-87.8 weeks). Progression free survival for all patients measured 29.6 weeks (95% CI 24.4-34.7 weeks). One year overall survival was 68% and 2 year overall survival was 20%. Major treatment toxicities included grade 3/4 neutropenia and thrombocytopenia in 74 and 33% of treatment cycles, respectively. One patient died due to sepsis. These promising results are consistent with continued clinical investigation; a phase III clinical trial with whole body hyperthermia as the independent variable has been initiated.

AB - We performed a phase II study combining 41.8°C whole body hyperthermia with ICE chemotherapy, i.e. ifosfamide (5 g/m2), carboplatin (300 mg/m2) and etoposide (150 mg/m2 on days 2 and 3), administered every 4 weeks, for patients with malignant pleural mesothelioma. Of 27 chemonäive, non-metastatic patients enrolled, 25 patients were evaluable for response. Overall response rate was 20% (five partial remissions; 95% CI 8.9-39.1%). Median survival time from the start of treatment for all patients was 76.6 weeks (95% CI 65.4-87.8 weeks). Progression free survival for all patients measured 29.6 weeks (95% CI 24.4-34.7 weeks). One year overall survival was 68% and 2 year overall survival was 20%. Major treatment toxicities included grade 3/4 neutropenia and thrombocytopenia in 74 and 33% of treatment cycles, respectively. One patient died due to sepsis. These promising results are consistent with continued clinical investigation; a phase III clinical trial with whole body hyperthermia as the independent variable has been initiated.

UR - https://www.scopus.com/pages/publications/0037374232

U2 - 10.1016/S0169-5002(02)00536-6

DO - 10.1016/S0169-5002(02)00536-6

M3 - Journal articles

C2 - 12609573

AN - SCOPUS:0037374232

SN - 0169-5002

VL - 39

SP - 339

EP - 345

JO - Lung Cancer

JF - Lung Cancer

IS - 3

ER -

Ifosfamide, carboplatin and etoposide combined with 41.8°C whole body hyperthermia for malignant pleural mesothelioma

Abstract

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