TY - JOUR
T1 - I405V polymorphism of CETP gene and lipid profile in women with endometriosis
AU - Sahmani, Mehdi
AU - Ghaleh, Talaat Dabbaghi
AU - Darabi, Maryam
AU - Darabi, Masoud
AU - Rashvand, Zahra
AU - Najafipour, Reza
N1 - Funding Information:
The authors report no conflicts of interest. This study was financially supported by the Cellular and Molecular Research Center, Qazvin University of Medical Sciences and the authors acknowledge the Drug Applied Research Center, Tabriz University of Medical Sciences.
PY - 2013/7
Y1 - 2013/7
N2 - Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.
AB - Genetic factors have an important role in the pathophysiology of endometriosis. In addition, abnormalities in lipid profile and intrinsic inflammatory status are associated with disease progression. The purpose of this study was to evaluate the effect of the I405V polymorphism of cholesteryl ester transfer protein (CETP) gene and lipid profile with the risk of endometriosis in women. Ninety-seven women with laparoscopy-diagnosed endometriosis were recruited for this study, and 107 patients with no evidence of endometriosis confirmed by laparoscopy served as controls. Samples were analyzed for polymorphism of the CETP gene using polymerase chain reaction-restriction fragment length polymorphism-based methods. After adjustment for body mass index, high-density lipoprotein-C and low-density lipoprotein-C, the risk of endometriosis in patients with normal genotype homozygous was more of the rare allele (p < 0.001, odds ratio = 0.21, 95% confidence interval = 0.09-0.45). Our results suggest that I405V polymorphism of CETP gene plays an important role as independent factor in the risk of endometriosis in women.
UR - http://www.scopus.com/inward/record.url?scp=84879306455&partnerID=8YFLogxK
U2 - 10.3109/09513590.2013.797396
DO - 10.3109/09513590.2013.797396
M3 - Journal articles
C2 - 23772784
AN - SCOPUS:84879306455
SN - 0951-3590
VL - 29
SP - 712
EP - 715
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
IS - 7
ER -
