Hypoxia-inducible factor-1: More than a hypoxia-inducible transcription factor

Thomas Hellwig-Bürgel; Daniel Phillip Stiehl; Wolfgang Jelkmann

Hypoxia-inducible factor-1: More than a hypoxia-inducible transcription factor

Thomas Hellwig-Bürgel, Daniel Phillip Stiehl, Wolfgang Jelkmann

Institute of Physiology

Abstract

Transcription is an energy-consuming process. From an economical view it is reasonable that not all genes are transcribed simultaneously in one cell. Indeed, most genes are transcribed only when a specific gene product is needed. Regulation of gene expression is mainly achieved by the coordinate interplay of different transcription factors (TFs) and transcriptional coactivators with DNA-dependent RNA-polymerases. To gain spatial and temporal control in this process, TFs have to fulfill two prerequisites: sequence specificity and inducibility.

Original language	English
Title of host publication	Oxygen Sensing : Responses and Adaption to Hypoxia
Number of pages	16
Publisher	CRC Press
Publication date	01.01.2003
Pages	93-108
ISBN (Print)	9780824709600
ISBN (Electronic)	9780824748456
Publication status	Published - 01.01.2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

Cite this

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Hypoxia-inducible factor-1: More than a hypoxia-inducible transcription factor

Abstract

UN SDGs

Research Areas and Centers

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