Hypoxia-inducible factor-1: More than a hypoxia-inducible transcription factor

Thomas Hellwig-Bürgel, Daniel Phillip Stiehl, Wolfgang Jelkmann

3 Citations (Scopus)


Transcription is an energy-consuming process. From an economical view it is reasonable that not all genes are transcribed simultaneously in one cell. Indeed, most genes are transcribed only when a specific gene product is needed. Regulation of gene expression is mainly achieved by the coordinate interplay of different transcription factors (TFs) and transcriptional coactivators with DNA-dependent RNA-polymerases. To gain spatial and temporal control in this process, TFs have to fulfill two prerequisites: sequence specificity and inducibility.

Original languageEnglish
Title of host publicationOxygen Sensing : Responses and Adaption to Hypoxia
Number of pages16
PublisherCRC Press
Publication date01.01.2003
ISBN (Print)9780824709600
ISBN (Electronic)9780824748456
Publication statusPublished - 01.01.2003

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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