Hypothermia induced by atypical neuroleptics

Markus Schwaninger*, Matthias Weisbrod, Stefan Schwab, Martin Schröder, Werner Hacke

*Corresponding author for this work
34 Citations (Scopus)


Hypothermia is a potentially life-threatening emergency. This article examines the case of a 34-year-old, mentally retarded man who experienced three episodes of hypothermia during recurrent exposure to pipamperone. After the pipamperone dose was largely reduced, no further hypothermic episodes occurred. Nine other cases of hypothermia with neuroleptic treatment were reported to the German Federal Institute of Drugs and Medical Devices from 1988 to 1997. A review of the cases revealed that nine often patients were treated with drugs that are potent antagonists of 5-HT2 receptors. In conjunction with experimental data, this suggests that antipsychotics with a strong 5HT2 antagonistic component might be associated with hypothermia. Most of the newly developed 'atypical' neuroleptic drugs belong to this group. Therefore, special attention for hypothermia is warranted during the use of 'atypical' neuroleptics.

Original languageEnglish
JournalClinical Neuropharmacology
Issue number6
Pages (from-to)344-346
Number of pages3
Publication statusPublished - 01.11.1998

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


Dive into the research topics of 'Hypothermia induced by atypical neuroleptics'. Together they form a unique fingerprint.

Cite this