Humoral immunity and long-lived plasma cells

Rudolf A. Manz*, Sergio Arce, Giuliana Cassese, Anja E. Hauser, Falk Hiepe, Andreas Radbruch

*Corresponding author for this work
177 Citations (Scopus)


A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.

Original languageEnglish
JournalCurrent Opinion in Immunology
Issue number4
Pages (from-to)517-521
Number of pages5
Publication statusPublished - 01.08.2002

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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