TY - JOUR
T1 - Humoral immunity and long-lived plasma cells
AU - Manz, Rudolf A.
AU - Arce, Sergio
AU - Cassese, Giuliana
AU - Hauser, Anja E.
AU - Hiepe, Falk
AU - Radbruch, Andreas
N1 - Funding Information:
This work was supported by the Deutsche Forschungsgemeinschaft grant numbers MA 2273 and SFB421/C4.
PY - 2002/8/1
Y1 - 2002/8/1
N2 - A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.
AB - A selected fraction of plasmablasts enters the compartment of nondividing, long-lived plasma cells to maintain humoral antibody memory. In accord with a current model for lymphocyte homeostasis, the lifetime of long-lived plasma cells is probably regulated by competition for a limited number of survival niches present in splenic red pulp, bone marrow and inflamed tissue. Plasma cells secreting autoantibodies specific for some, but not all, self-antigens are probably 'allowed' to enter the compartment of long-lived plasma cells and provide antibody-mediated 'autoimmune memory' that is resistant to conventional therapies.
UR - http://www.scopus.com/inward/record.url?scp=0036668252&partnerID=8YFLogxK
U2 - 10.1016/S0952-7915(02)00356-4
DO - 10.1016/S0952-7915(02)00356-4
M3 - Scientific review articles
C2 - 12088688
AN - SCOPUS:0036668252
SN - 0952-7915
VL - 14
SP - 517
EP - 521
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -
