Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region

D Shimron-Abarbanell; J Erdmann; I R Vogt; S P Bryant; N K Spurr; M Knapp; P Propping; M M Nöthen

doi:10.1006/bbrc.1997.6390

Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region

D Shimron-Abarbanell, J Erdmann, I R Vogt, S P Bryant, N K Spurr, M Knapp, P Propping, M M Nöthen

Institute of Cardiogenetics

University of Bonn

21 Citations (Scopus)

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of sensory, motor, and cortical functions by activating multiple 5-HT receptor subtypes. In the present study we performed a systematic mutation scan of the complete coding region of the 5-HT5A receptor to explore its variability in the general population. Investigating 46 unrelated healthy subjects by single-strand conformation analysis no sequence changes of likely functional relevance were observed. The detection of a frequent G-->C substitution at position -19 was used for fine scale linkage mapping of the 5-HT5A gene. Employing a polymerase-chain-reaction based assay we genotyped 7 CEPH families (Centre d'Etude du Polymorphisme Humaine) and mapped the receptor to genetic markers on chromosome 7q34-q36.

Original language	English
Journal	Biochemical and Biophysical Research Communications
Volume	233
Issue number	1
Pages (from-to)	6-9
Number of pages	4
ISSN	0006-291X
DOIs	https://doi.org/10.1006/bbrc.1997.6390
Publication status	Published - 07.04.1997

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Shimron-Abarbanell, D., Erdmann, J., Vogt, I. R., Bryant, S. P., Spurr, N. K., Knapp, M., Propping, P., & Nöthen, M. M. (1997). Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region. Biochemical and Biophysical Research Communications, 233(1), 6-9. https://doi.org/10.1006/bbrc.1997.6390

@article{d092af73009c4ecb8a2a1611b0bdccd9,

title = "Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region",

abstract = "Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of sensory, motor, and cortical functions by activating multiple 5-HT receptor subtypes. In the present study we performed a systematic mutation scan of the complete coding region of the 5-HT5A receptor to explore its variability in the general population. Investigating 46 unrelated healthy subjects by single-strand conformation analysis no sequence changes of likely functional relevance were observed. The detection of a frequent G-->C substitution at position -19 was used for fine scale linkage mapping of the 5-HT5A gene. Employing a polymerase-chain-reaction based assay we genotyped 7 CEPH families (Centre d'Etude du Polymorphisme Humaine) and mapped the receptor to genetic markers on chromosome 7q34-q36.",

author = "D Shimron-Abarbanell and J Erdmann and Vogt, \{I R\} and Bryant, \{S P\} and Spurr, \{N K\} and M Knapp and P Propping and N{\"o}then, \{M M\}",

year = "1997",

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doi = "10.1006/bbrc.1997.6390",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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Shimron-Abarbanell, D, Erdmann, J, Vogt, IR, Bryant, SP, Spurr, NK, Knapp, M, Propping, P & Nöthen, MM 1997, 'Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region', Biochemical and Biophysical Research Communications, vol. 233, no. 1, pp. 6-9. https://doi.org/10.1006/bbrc.1997.6390

Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region. / Shimron-Abarbanell, D; Erdmann, J; Vogt, I R et al.
In: Biochemical and Biophysical Research Communications, Vol. 233, No. 1, 07.04.1997, p. 6-9.

Research output: Journal Articles › Journal articles › Research › peer-review

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T1 - Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region

AU - Shimron-Abarbanell, D

AU - Erdmann, J

AU - Vogt, I R

AU - Bryant, S P

AU - Spurr, N K

AU - Knapp, M

AU - Propping, P

AU - Nöthen, M M

PY - 1997/4/7

Y1 - 1997/4/7

N2 - Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of sensory, motor, and cortical functions by activating multiple 5-HT receptor subtypes. In the present study we performed a systematic mutation scan of the complete coding region of the 5-HT5A receptor to explore its variability in the general population. Investigating 46 unrelated healthy subjects by single-strand conformation analysis no sequence changes of likely functional relevance were observed. The detection of a frequent G-->C substitution at position -19 was used for fine scale linkage mapping of the 5-HT5A gene. Employing a polymerase-chain-reaction based assay we genotyped 7 CEPH families (Centre d'Etude du Polymorphisme Humaine) and mapped the receptor to genetic markers on chromosome 7q34-q36.

AB - Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that mediates a wide range of sensory, motor, and cortical functions by activating multiple 5-HT receptor subtypes. In the present study we performed a systematic mutation scan of the complete coding region of the 5-HT5A receptor to explore its variability in the general population. Investigating 46 unrelated healthy subjects by single-strand conformation analysis no sequence changes of likely functional relevance were observed. The detection of a frequent G-->C substitution at position -19 was used for fine scale linkage mapping of the 5-HT5A gene. Employing a polymerase-chain-reaction based assay we genotyped 7 CEPH families (Centre d'Etude du Polymorphisme Humaine) and mapped the receptor to genetic markers on chromosome 7q34-q36.

U2 - 10.1006/bbrc.1997.6390

DO - 10.1006/bbrc.1997.6390

M3 - Journal articles

C2 - 9144385

SN - 0006-291X

VL - 233

SP - 6

EP - 9

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

Human 5-HT5A receptor gene: Systematic screening for DNA sequence variation and linkage mapping on chromosome 7q34-q36 using a polymorphism in the 5' untranslated region

Abstract

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