TY - JOUR
T1 - HPA-1 carrier status and thrombocytopenia in preterm infants with a birth weight below 1500 grams
AU - Göpel, Wolfgang
AU - Fehlau, Kirstin
AU - Kohl, Martina
AU - Schultz, Christian
AU - Möller, Jens
N1 - Funding Information:
Acknowledgment: The authors thank Lynn Ellenberg for excellent laboratory assistance and Dr. Friedrich of the Institute for Medical Statistics of the University of Lçbeck for the logistic regression analysis. This study was supported by grant GO-955/1-1 from the Deutsche Forschungsgemeinschaft.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.
AB - Objective: In cohorts of infants with proven neonatal alloimmune thrombocytopenia (NAIT) an unusual high rate of preterm infants has been reported, raising the question of whether NAIT contributes to the high rate of intracranial hemorrhage in preterm infants. Methods: We genotyped the HPA-1-allele in a large cohort of term (n = 205) and very low birth weight infants (VLBW-infants, n = 299) with polymerase-chain-reaction and restriction enzyme digestion. Results: HPA-la/b is the only fetal HPA-1-genotype in which alloimmunization and NAIT could occur. Genotype distribution did not differ between term and VLBW-infants (p = 0.26). Furthermore, neither HPA-la/b genotype nor platelet count at birth were of significant prognostic value in predicting subsequent intracranial haemorrhage or death in VLBW-infants (p = 0.93 and V = 0.19 respectively). Conclusion: Our data did not support the hypothesis that routine screening of preterm infants or their mothers for HPA-1-genotype is of additional value in the care of these infants.
UR - http://www.scopus.com/inward/record.url?scp=0036117870&partnerID=8YFLogxK
U2 - 10.1515/JPM.2002.023
DO - 10.1515/JPM.2002.023
M3 - Journal articles
C2 - 12012640
AN - SCOPUS:0036117870
SN - 0300-5577
VL - 30
SP - 176
EP - 178
JO - Journal of Perinatal Medicine
JF - Journal of Perinatal Medicine
IS - 2
ER -
