Hormonal management of complete androgen insensitivity syndrome from adolescence onward

Silvano Bertelloni*, Eleonora Dati, Giampiero I. Baroncelli, Olaf Hiort

*Corresponding author for this work
26 Citations (Scopus)


Complete androgen insensitivity syndrome (CAIS) represents a main disorder of sex development. Women with CAIS may have their gonads removed before, during or after adolescence, thus requiring hormonal replacement therapy to induce puberty and/or maintain secondary sexual characteristics, to optimize bone mass accrual, and to promote physical and social well-being. Usually estrogens are used for this purpose, but formulations and doses should be better defined in multicentric prospective studies. Some women started testostosterone as hormonal replacement therapy, but this practice remains anecdotal. Bone health remains a crucial aspect in the management of persons with CAIS, but few sound data are available to guide clinical practice.

Original languageEnglish
JournalHormone Research in Paediatrics
Issue number6
Pages (from-to)428-433
Number of pages6
Publication statusPublished - 12.2011

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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