Hives but no urticaria—what could it be?

Mathias Sulk*, Carolin C. Albers, Maria Wulf, Stephan A. Braun, Christoph M. Hammers, Guido Heine

*Corresponding author for this work

Abstract

Urticaria is a common inflammatory dermatosis characterized by transient, usually intensely itching wheals mediated by mast cells. Urticarial lesions can also be mimicked by other skin diseases. Differential diagnoses of urticaria should be considered if the single urticarial skin lesion persists for more than 24 h, if hyperpigmentation, scaling, or blistering occurs, if the lesions are not itching, or if fever or arthralgias are reported. In these cases, histologic examination and thorough serologic diagnostic may help to differentiate other dermatoses, such as vasculitis, autoimmune bullous skin diseases, drug reactions, or autoinflammatory syndromes. This article summarizes common differential diagnoses of urticaria.

Original languageEnglish
JournalAllergo Journal International
Volume32
Issue number8
Pages (from-to)309-317
Number of pages9
DOIs
Publication statusPublished - 12.2023

Funding

M. Sulk received honoraria and travel support from AstraZeneca, Bencard, BioCryst, CSL-Behring, HAL Allergy, Novartis, Sanofi, Takeda, Unna Academy outside the submitted work; memberships in ABD, AeDA, DGAKI, EAACI. S.A. Braun received honoraria and travel support from Almirall, Amgen, Beiersdorf, Kyowa Kirin, Lilly, L’Oréal, Novartis outside the submitted work; memberships in ADF, ADH, DDG, ISDP. Financial support received from the German Federal Ministry of Research and Education (FKZ: 16KISA115K, 01IS22004B) and the EU (FKZ: 16KISA115K) and Galderma. C.M. Hammers received honoraria from JJP Biologics, Argenx and viDATherapeutics outside of this work. Financial support received from Deutsche Forschungsgemeinschaft, Collaborative Research Center (CRC) 1526—Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU)—Insights from Pemphigoid Diseases (Grant No.: 454193335), Project A05. Memberships in DGAKI, DgfI, ADF, DDG, ESDR, JSID. G. Heine received honoraria from Allergopharma, Abbvie, Biotest, Eli-Lilly and Sanofi outside this work; memberships in DGAKI, DDG, DgfI, BDG, ABD, DKG. Financial support received from Deutsche Forschungsgemeinschaft, Collaborative Research Center (CRC) 1526—Pathomechanisms of Antibody-mediated Autoimmunity (PANTAU)—Insights from Pemphigoid Diseases (Grant No.: 454193335), Project A02 and S01. Memberships in ABD, DGAKI, EAACI. C.C. Albers and M. Wulf declare that they have no competing interests.

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)
  • Centers: Center for Research on Inflammation of the Skin (CRIS)

DFG Research Classification Scheme

  • 2.22-19 Dermatology
  • 2.21-05 Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  • SDG 3 - Good Health and Well-being

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  • CRC 1526, PANTAU: Pathomechanisms of Antibody-mediated Autoimmunity

    Sadik, C. (Speaker, Coordinator), Zillikens, D. (Speaker, Coordinator), Scheffold, A. (Principal Investigator (PI)), Schmidt, E. (Principal Investigator (PI)), Heine, G. (Principal Investigator (PI)), Manz, R. (Principal Investigator (PI)), Köhl, J. (Principal Investigator (PI)), Ludwig, R. (Principal Investigator (PI)), Peipp, M. (Principal Investigator (PI)), Hammers, M. C. (Principal Investigator (PI)), Verschoor, A. (Principal Investigator (PI)), Karsten, C. (Principal Investigator (PI)), Nimmerjahn, F. (Principal Investigator (PI)), Hutloff, A. (Principal Investigator (PI)), Ibrahim, S. (Principal Investigator (PI)), Wettschureck, N. (Principal Investigator (PI)), Bieber, K. (Principal Investigator (PI)), Schilf, P. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Hirose, M. (Principal Investigator (PI)), Vaeth, M. (Principal Investigator (PI)), Baines, J. F. (Principal Investigator (PI)), Bacher, P. (Principal Investigator (PI)), Hoffmann, M. (Principal Investigator (PI)), Busch, H. S. (Principal Investigator (PI)), Höppner, M. (Principal Investigator (PI)), Becker, M. (Principal Investigator (PI)), Holtsche, M. M. (Principal Investigator (PI)), Fähnrich, A. (Principal Investigator (PI)), Szymczak, S. (Principal Investigator (PI)), Murthy, S. (Principal Investigator (PI)) & Lux, A. (Principal Investigator (PI))

    01.01.22 → …

    Project: DFG Joint Research › DFG Collaborative Research Centers (CRC)

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