Histopathology of anti-laminin 5 mucous membrane pemphigoid

Christian Rose, Enno Schmidt, Andreas Kerstan, Sybille Thoma-Uszynski, Ulrich Wesselmann, Ulrich Käsbohrer, Detlef Zillikens, Iakov Shimanovich


    BACKGROUND: Anti-laminin 5 mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the major basement membrane component laminin 5 (laminin 332, epiligrin).

    OBJECTIVE AND METHODS: We reviewed 17 biopsy specimens from 9 patients with anti-laminin 5 MMP in an attempt to define typical histopathologic features of the disease.

    RESULTS: Fifteen specimens showed subepidermal blister formation, while two biopsy specimens revealed an epithelial ulcer. In 11 biopsies a sparse to moderate inflammatory infiltrate composed of lymphocytes and neutrophils with some eosinophils was observed. Four biopsies showed a dense infiltrate dominated by neutrophils in two cases and by eosinophils in one case. The remaining biopsy revealed a dense lymphoplasmacellular infiltrate without granulocytes. Scarring of the upper dermis was present only in 5 specimens. Immunohistochemical analysis localized type IV collagen to the dermal side of the blister, suggesting that split formation occurred within the lamina lucida of the cutaneous basement membrane.

    LIMITATIONS: The number of patients studied was relatively small.

    CONCLUSIONS: Histopathology of anti-laminin 5 MMP is characterized by subepidermal blistering and a sparse to moderate superficial lymphohistiocytic infiltrate with neutrophils and/or eosinophils. Both infiltrate density and composition may vary, making anti-laminin 5 MMP indistinguishable from other autoimmune subepidermal blistering diseases by histopathology alone. Scarring is present only in a minority of cases and is not a sensitive clue to the diagnosis of anti-laminin 5 MMP.

    Original languageEnglish
    JournalJournal of the American Academy of Dermatology
    Issue number3
    Pages (from-to)433-40
    Number of pages8
    Publication statusPublished - 09.2009


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