Histopathological features and ann arbor stage in periocular lymphoma

Marco Zschoche*, Annette Zimpfer, Björn O. Scheef, Anselm M. Jünemann, Rudolf F. Guthoff, Christian Junghanss, Guido Hildebrandt, Steffen Emmert, Andreas Erbersdobler, Günther Kundt, Vinodh Kakkassery

*Corresponding author for this work
2 Citations (Scopus)


Background: To evaluate biodata, symptoms/signs, lymphoma type, localization, stage level, treatment choice and outcome of ocular adnexal lymphoma (OAL). Patients and Methods: A single-center retrospective analysis of 56 patients with OAL was performed from 1998 to 2018. Results: OAL involved the orbit in 44.6%, the conjunctiva in 32.1%, the lacrimal apparatus in 14.3% and the eyelid in 8.93%. Extranodal marginal zone B-cell lymphoma (EMZL) was found in 60.7%, follicular lymphoma (FL) in 21.4%, diffuse large Bcell lymphoma in 7.14%, mantle cell lymphoma in 5.36% and chronic lymphatic leukaemia in 5.36% patients. No relapse was seen in 76%. EMZL and FL had a significantly better overall survival compared to other lymphoma types (p=0.002). Patients with Ann Arbor stage IE had a significantly better prognosis than those with stages higher than IE (p=0.048). Conclusion: Our data suggest that clinicopathological features such as Ann Arbor stage influence survival.

Original languageEnglish
JournalIn Vivo
Issue number4
Pages (from-to)1965-1974
Number of pages10
Publication statusPublished - 08.2020

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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