Histopathologic findings in a novel decellularized pulmonary homograft: An autopsy study

Friedhelm Sayk; Inge Bos; Ute Schubert; Thilo Wedel; Hans H. Sievers

doi:10.1016/j.athoracsur.2003.11.049

Histopathologic findings in a novel decellularized pulmonary homograft: An autopsy study

Friedhelm Sayk^*, Inge Bos, Ute Schubert, Thilo Wedel, Hans H. Sievers

^*Corresponding author for this work

45 Citations (Scopus)

Abstract

Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.

Original language	English
Journal	Annals of Thoracic Surgery
Volume	79
Issue number	5
Pages (from-to)	1755-1758
Number of pages	4
ISSN	0003-4975
DOIs	https://doi.org/10.1016/j.athoracsur.2003.11.049
Publication status	Published - 05.2005

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10.1016/j.athoracsur.2003.11.049

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title = "Histopathologic findings in a novel decellularized pulmonary homograft: An autopsy study",

abstract = "Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.",

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AU - Sayk, Friedhelm

AU - Bos, Inge

AU - Schubert, Ute

AU - Wedel, Thilo

AU - Sievers, Hans H.

PY - 2005/5

Y1 - 2005/5

N2 - Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.

AB - Innovative valved conduits for reconstruction of the right ventricular outflow tract are desirable to overcome the risk of valve deterioration of conventional homografts. This study describes the histopathology of a novel decellularized pulmonary homograft (SynerGraft) implanted in the right ventricular outflow tract of a 60-year-old man 5 weeks before death. The histomorphology of this decellularized homograft showed integrity of its extracellular matrix and a gradual cellular infiltrate consisting predominantly of macrophages, resembling an early nonspecific inflammatory phase of recellularization without any signs of a specific immunologic interference 5 weeks after implantation. Whether this morphologic appearance precedes the desired repopulation with autologous fibroblasts remains to be established.

UR - https://www.scopus.com/pages/publications/18144387569

U2 - 10.1016/j.athoracsur.2003.11.049

DO - 10.1016/j.athoracsur.2003.11.049

M3 - Journal articles

C2 - 15854972

AN - SCOPUS:18144387569

SN - 0003-4975

VL - 79

SP - 1755

EP - 1758

JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

IS - 5

ER -

Histopathologic findings in a novel decellularized pulmonary homograft: An autopsy study

Abstract

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