Abstract
Background: Release of histamine from mast cells and basophils in inflammatory diseases of the nose and paranasal sinuses has been demonstrated in allergic and non-allergic processes. Methods: A selective literature search was conducted in PubMed and Medline, and publications in German-language journals were additionally analyzed. Results: The histamine receptors H 1 –H 4 play a role in otorhinolaryngologic inflammatory diseases. To date, the histamine receptor subtype 4 (H 4 R), which is functionally expressed by immune cells in chronic inflammatory diseases, has received little attention. Stimulation of H 4 R influences the release of cytokines and chemokines as well as the migration behavior of immune cells. In animal models blockade of H 4 R reduced inflammation symptoms and pruritus. Conclusions: H 4 R plays a key role in the pathogenesis of chronic inflammatory diseases and may represent an interesting future therapeutic target.
| Translated title of the contribution | Histamine receptors in chronic inflammatory diseases of the nose and paranasal sinuses |
|---|---|
| Original language | German |
| Journal | HNO |
| Pages (from-to) | 389–400 |
| Number of pages | 12 |
| ISSN | 0017-6192 |
| DOIs | |
| Publication status | Published - 03.04.2019 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
