TY - JOUR
T1 - Hippocampal volume in subjects at high risk of psychosis
T2 - A longitudinal MRI study
AU - Walter, Anna
AU - Studerus, Erich
AU - Smieskova, Renata
AU - Kuster, Pascal
AU - Aston, Jacqueline
AU - Lang, Undine E.
AU - Radue, Ernst Wilhelm
AU - Riecher-Rössler, Anita
AU - Borgwardt, Stefan
N1 - Funding Information:
This research was supported by a personal grant (SJB) provided by the Swiss National Science Foundation (PBBSB 32323B_119382). The sponsor of the study had no role in study design, collection, analysis, interpretation of data, writing of this report, and in the decision to submit the paper for publication.
PY - 2012/12
Y1 - 2012/12
N2 - Introduction: The hippocampal formation has been studied extensively in schizophrenic psychoses and alterations in hippocampal anatomy have been consistently reported. Chronic schizophrenia seems to be associated with bilateral hippocampal volume (HV) reduction, while in patients with an at-risk mental state (ARMS) there are contradictory results. This is the first region of interest (ROI) based follow-up MRI study of hippocampal volume comparing ARMS individuals with and without transition to psychosis. The aim was to investigate the timing of HV changes in ARMS in the early phase of psychosis. Methods: Magnetic resonance imaging data from 18 antipsychotic-naïve individuals with an ARMS were collected within the FePsy-clinic for early detection of psychoses. During follow-up 8 subjects transitioned to psychosis (ARMS-T) and 10 did not (ARMS-NT). Subjects were re-scanned after the onset of psychosis or at the end of the follow-up if they did not develop psychosis. Results: Across both groups there was a significant decrease in HV over time (p < 0.05). There was no significant difference in progression between ARMS-T and ARMS-NT. Antipsychotic medication at follow up was associated with increased HV (p < 0.05). Conclusions: We found a decrease of HV over time in subjects with an ARMS, independently of clinical outcome. We may speculate that the decrease of HV over time might reflect brain degeneration processes.
AB - Introduction: The hippocampal formation has been studied extensively in schizophrenic psychoses and alterations in hippocampal anatomy have been consistently reported. Chronic schizophrenia seems to be associated with bilateral hippocampal volume (HV) reduction, while in patients with an at-risk mental state (ARMS) there are contradictory results. This is the first region of interest (ROI) based follow-up MRI study of hippocampal volume comparing ARMS individuals with and without transition to psychosis. The aim was to investigate the timing of HV changes in ARMS in the early phase of psychosis. Methods: Magnetic resonance imaging data from 18 antipsychotic-naïve individuals with an ARMS were collected within the FePsy-clinic for early detection of psychoses. During follow-up 8 subjects transitioned to psychosis (ARMS-T) and 10 did not (ARMS-NT). Subjects were re-scanned after the onset of psychosis or at the end of the follow-up if they did not develop psychosis. Results: Across both groups there was a significant decrease in HV over time (p < 0.05). There was no significant difference in progression between ARMS-T and ARMS-NT. Antipsychotic medication at follow up was associated with increased HV (p < 0.05). Conclusions: We found a decrease of HV over time in subjects with an ARMS, independently of clinical outcome. We may speculate that the decrease of HV over time might reflect brain degeneration processes.
UR - http://www.scopus.com/inward/record.url?scp=84869878710&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2012.10.013
DO - 10.1016/j.schres.2012.10.013
M3 - Journal articles
C2 - 23123134
AN - SCOPUS:84869878710
VL - 142
SP - 217
EP - 222
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -