TY - JOUR
T1 - Hippocampal volume in subjects at clinical high-risk for psychosis
T2 - A systematic review and meta-analysis
AU - Walter, Anna
AU - Suenderhauf, Claudia
AU - Harrisberger, Fabienne
AU - Lenz, Claudia
AU - Smieskova, Renata
AU - Chung, Yoonho
AU - Cannon, Tyrone D.
AU - Bearden, Carrie E.
AU - Rapp, Charlotte
AU - Bendfeldt, Kerstin
AU - Borgwardt, Stefan
AU - Vogel, Tobias
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Several magnetic resonance imaging studies have reported reductions in hippocampal volume in patients with psychosis. It is unclear whether structural abnormalities predate illness onset. We conducted a detailed, systematic literature search for studies reporting hippocampal volume in subjects with clinical high-risk, compared to healthy controls. The overall sample size comprised 1429 subjects. Meta-analysis revealed no difference for left, but a small, albeit significant, difference for right hippocampal volume, such that clinical high-risk patients had slightly smaller hippocampal volume than healthy controls (g = 0.24, p = 0.0418). Meta-regression indicated a moderating effect of manual tracing approach, due to one outlying site. The small difference on the right side did not remain significant (g = 0.14, 95%CI = [−0.03–0.32], p = 0.11) after removal of this outlier. This meta-analysis suggests that there is no reduction in hippocampal volume before transition to psychosis and hippocampal volume cannot be used as a biomarker in clinical high-risk individuals.
AB - Several magnetic resonance imaging studies have reported reductions in hippocampal volume in patients with psychosis. It is unclear whether structural abnormalities predate illness onset. We conducted a detailed, systematic literature search for studies reporting hippocampal volume in subjects with clinical high-risk, compared to healthy controls. The overall sample size comprised 1429 subjects. Meta-analysis revealed no difference for left, but a small, albeit significant, difference for right hippocampal volume, such that clinical high-risk patients had slightly smaller hippocampal volume than healthy controls (g = 0.24, p = 0.0418). Meta-regression indicated a moderating effect of manual tracing approach, due to one outlying site. The small difference on the right side did not remain significant (g = 0.14, 95%CI = [−0.03–0.32], p = 0.11) after removal of this outlier. This meta-analysis suggests that there is no reduction in hippocampal volume before transition to psychosis and hippocampal volume cannot be used as a biomarker in clinical high-risk individuals.
UR - http://www.scopus.com/inward/record.url?scp=84994330161&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2016.10.007
DO - 10.1016/j.neubiorev.2016.10.007
M3 - Scientific review articles
C2 - 27773693
AN - SCOPUS:84994330161
SN - 0149-7634
VL - 71
SP - 680
EP - 690
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -
