Abstract
To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.
| Original language | English |
|---|---|
| Article number | 2203012 |
| Journal | International Journal on Magnetic Particle Imaging |
| Volume | 8 |
| Issue number | 1 |
| ISSN | 2365-9033 |
| DOIs | |
| Publication status | Published - 2022 |
Funding
Research funding: The authors thankfully acknowledge the financial support by the German Research Foundation (DFG GR 5287/2-1) The Fraunhofer IMTE is supported by the EU (EFRE) and the State Schleswig-Holstein, Germany (Project: IMTE – Grant: 124 20 002 / LPW-E1.1.1/1536. The authors thankfully acknowledge the financial support by the German Research Foun-dation (DFG GR 5287/2-1) The Fraunhofer IMTE is supported by the EU (EFRE) and the State Schleswig-Holstein, Germany (Project: IMTE ? Grant: 124 20 002 / LPW-E1.1.1/1536.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure
Research Areas and Centers
- Academic Focus: Biomedical Engineering
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