High gradient nested Halbach system for steering magnetic particles

Yvonne Blancke Soares; Matthias Graeser; Justin Ackers; Anna Bakenecker; Thomas Friedrich; Jonas Schumacher; Kerstin Lüdtke-Buzug; Peter Blümler; Thorsten M. Buzug

doi:10.18416/ijmpi.2022.2203012

High gradient nested Halbach system for steering magnetic particles

Yvonne Blancke Soares^*, Matthias Graeser, Justin Ackers, Anna Bakenecker, Thomas Friedrich, Jonas Schumacher, Kerstin Lüdtke-Buzug, Peter Blümler, Thorsten M. Buzug

^*Corresponding author for this work

Institute of Medical Engineering

Johannes Gutenberg University Mainz

Abstract

To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.

Original language	English
Article number	2203012
Journal	International Journal on Magnetic Particle Imaging
Volume	8
Issue number	1
ISSN	2365-9033
DOIs	https://doi.org/10.18416/ijmpi.2022.2203012
Publication status	Published - 2022

Research Areas and Centers

Academic Focus: Biomedical Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18416/ijmpi.2022.2203012

Cite this

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title = "High gradient nested Halbach system for steering magnetic particles",

abstract = "To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.",

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T1 - High gradient nested Halbach system for steering magnetic particles

AU - Soares, Yvonne Blancke

AU - Graeser, Matthias

AU - Ackers, Justin

AU - Bakenecker, Anna

AU - Friedrich, Thomas

AU - Schumacher, Jonas

AU - Lüdtke-Buzug, Kerstin

AU - Blümler, Peter

AU - Buzug, Thorsten M.

PY - 2022

Y1 - 2022

N2 - To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.

AB - To transport drugs within the brain to their desired application site it is necessary to overcome the blood brain barrier (BBB). To protect the brain from the penetration of harmful substances, the BBB forms an endogenous protection. Different approaches exist to overcome the BBB. One possible approach are magnetic nanoparticles which can be used to move drugs through the blood-brain barrier using magnetic guidance. The system described here consists of three rings of permanent magnets in Halbach configuration with an inner diameter of 5.5 cm, which generate a high gradient of 5.8 T/m at the center. The system is used as a demonstrator for future BBB experiments and to study the effect of application time and gradient strength on the transport mechanism.

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JO - International Journal on Magnetic Particle Imaging

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ER -

High gradient nested Halbach system for steering magnetic particles

Abstract

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